Japanese
TitleN-Isopropyl-P- [123I] Iodoamphetamineによる脳血流イメージの臨床的意義 - 脳血管障害を中心に -
Subtitle原著
Authors塩崎宏*, 岸川高*, 池田純*, 馬場博已*, 藤井清孝**, 柴崎浩***
Authors(kana)
Organization*佐賀医科大学放射線医学教室, **外科学 (脳神経外科) 教室, ***内科学 (神経内科) 教室
Journal核医学
Volume22
Number4
Page449-459
Year/Month1985/4
Article原著
Publisher日本核医学会
Abstract「要旨」N-isopropyl-P- [123I] iodoamphetamine (IMP) による脳血流イメージの臨床的意義について検討した. 脳血管障害を中心とした22例, 27検査を対象とし, IMPによるSPECTイメージの画像の質, 血流低下域の検出能に関するX線CTとの比較, SPECTイメージとプラナーイメージの比較検討を行った. 画像の質は深部の解像力に注目し, 基底核の分離の程度から "good" . "fair" , "poor" と評価したが, 78% (21/27) が "good" , または "fair" であり比較的良好であった. CTとの比較は25検査について行った. CTより大きな血流低下域を示した5検査のうち4検査でischemic penumbraの存在が示唆された. うち1例では浅側頭動脈 - 中大脳動脈吻合術後に虚血部位の血流の改善が確認された. CTより小さい血流低下域を示した8検査のうち3検査で梗塞に伴うhyperemiaの存在が示唆された. しかし他5検査ではいずれも小病変であり, CTより小さい血流低下域を示したのは解像力の限界によるものと考えられた. CTと同等の所見を呈したものは10検査であった. また2検査ではIMPイメージでは異常を指摘できなかった. SPECTイメージとプラナーイメージの比較は13検査について行ったが, SPECTイメージは病変の三次元的把握, 深部病変の検出においてすぐれていた. IMPによる脳血流イメージは血流という従来のX線CTとは異なる生理学的情報を提供し, 種々の脳血管障害の臨床評価に有用であると考えられた.
Practice臨床医学：一般
KeywordsN-isopropyl-p-[123I] iodoamphetamine, Cerebral blood flow, Single photon emission computed tomorgaphy, Computed tomography, Cerebrovascular disorder
English
TitleClinical Assessment of Cerebral Blood Flow Image Using N-Isopropyl-p-[123I] Iodoamphetamine (IMP) and Single Photon Emission Computed Tomography (SPECT)
SubtitleOriginal Articles
AuthorsHiroshi SHIOZAKI*, Takashi KISHIKAWA*, Jun IKEDA*, Hiromi BABA*, Kiyotaka FUJII**, Hiroshi SHIBASAKI***
Authors(kana)
Organization*Department of Radiology, Saga Medical School, **Department of Neurosurgery, Saga Medical School, ***Department of Internal Medicine, Saga Medical School
JournalThe Japanese Journal of nuclear medicine
Volume22
Number4
Page449-459
Year/Month1985/4
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] SPECT images of regional cerebral blood flow (rCBF) using N-isopropyl-p-[123I] iodoamphetamine IMP) were reviewed in twenty-two patients consisting of cerebrovascular disorders mostly. Twenty-seven IMP studies were obtained in these patients. Image quality of SPECT and detectability of abnormality compared with that of CT study were evaluated, and comparison of SPECT with planar images was done in the present study. Image quality of SPECT was assessed as good, fair, or poor according to the visualization of uninvolved basal ganglia. 78% (21/27) of the SPECT images were assessed as good or fair. 1n twenty-five studies, lesion detectability was compared about IMP and CT images. Four of five IMP studies which showed decreased rCBF areas larger than those on CT, presumably indicated the evidence of ischemic penumbra. In one case with left internal carotid artery occlusion, superficial-middle cerebral artery anastomosis was performed. Remarkable improvement of rCBF was demonstrated in the postoperative IMP study. Three of eight studies which showed decreased rCBF areas smaller than those on CT, probably indicated the evidence of hyperemia, but others were less diagnostic due to their small lesions and poor spatial resolution of the SPECT. In ten studies, the findings of IMP and CT were identical. In two studies, IMP SPECT images were not diagnostic. SPECT images were superior to the planar images with respect to its three dimensional reconstruction and recognition of deep lesions. In conclusion, IMP cerebral blood flow image gives physiologic information of rCBF which is considerably different from the findings on the CT, and may be useful in the clinical evaluation of cerebrovascular disorders.
PracticeClinical medicine
KeywordsN-isopropyl-p-[123I] iodoamphetamine, Cerebral blood flow, Single photon emission computed tomorgaphy, Computed tomography, Cerebrovascular disorder

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