| Japanese |
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| Title | ラット肥大心におけるタリウム - 201の摂取動態の検討 |
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| Subtitle | 原著 |
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| Authors | 鳥居幸雄*, 足立晴彦*, 木津明*, 中川雅夫*, 伊地知浜夫* |
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| Organization | *京都府立医科大学附属病院第二内科 |
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| Journal | 核医学 |
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| Volume | 22 |
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| Number | 4 |
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| Page | 439-447 |
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| Year/Month | 1985/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」肥大心における冠血流量と201Tl心筋摂取との関係について, ラットを用いて検討した. 対象を, 肥大心群 (H群, N=6) , diltiazem負荷群 (D群, N=10) , 正常対照群 (C群, N=14) の3群に分けた. 肥大心は, 金属クリップで上行大動脈を狭窄することにより作製し, diltiazem投与は0.3mg/kg/min, 5分間静注で行った. 冠血流量は, マイクロスフェアー法により測定した. この結果, 心重量は, H群で有意に増大し, また冠血流量と201Tl心筋摂取量の両者と有意な正相関を認めた. 冠血流量と心筋摂取率の関係は, 3群ともに負の相関が得られ, この両者の関係を比較するとD群とC群の間では有意差がないのに対し, H群では有意差を認めた. すなわち, D群の場合は, C群と同様に冠血流量の増加に見合った201Tl心筋摂取を認めたが, H群では201Tl摂取の相対的低下を認めた. これから, 肥大心筋細胞における201Tlの細胞膜通過障害とこれに関連する代謝異常が, 示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Thallium-201 myocardial uptake, Cardiac hypertrophy, Radioactive microsphere technique, Myocardial blood flow, Extraction fraction |
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| English |
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| Title | Myocardial Uptake of Thallium-201 in Rat with Cardiac Hypertrophy |
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| Subtitle | Original Articles |
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| Authors | Yukio TORII, Haruhiko ADACHI, Akira KIZU, Masao NAKAGAWA, Hamao IJICHI |
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| Organization | The Second Department of Internal Medicine, Kyoto Prefectural University of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 22 |
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| Number | 4 |
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| Page | 439-447 |
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| Year/Month | 1985/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The thallium-201 (TL) has been used in order to diagnose myocardial infarction and ischemia. Although it is well known that TL distributes in the myocardium in proportion to the distribution of coronary blood flow, the biological property of TL in the loaded myocardium remains unclear. We studied the myocardial uptake of TL in rat with cardiac hypertrophy. Experiments were performed in 30 anesthetized rats devided into 3 groups ; control group (C, N=14) , hypertrophy group (H, N=6) and diltiazem group (D, 0.3mg/kg/min. IV. N=10) . Cardiac hypertrophy was produced with the banding of the ascending aorta. Myocardial blood flow (MBF) was measured by microspheres labeled with Strontium-85. Cardiac weight was increased in H, and both MBF and TL uptake were proportionally increased. MBF was negatively correlated with the extraction fraction in C (r=-0.71) , in H (r=-0.66) and in D (r=-0.85) , and this relationship in H was significantly different from it in C (p<0.05) , but not in D. From these results, we concluded that TL uptake in H is not always dependant on MBF and affected by the altered metabolism of hypertrophied myocardium. |
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| Practice | Clinical medicine |
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| Keywords | Thallium-201 myocardial uptake, Cardiac hypertrophy, Radioactive microsphere technique, Myocardial blood flow, Extraction fraction |
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