| Japanese |
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| Title | 201Tl-Chlorideによる子宮体部癌の診断に関する研究 |
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| Subtitle | 原著 |
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| Authors | 渡辺肇* |
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| Authors(kana) | |
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| Organization | *東邦大学医学部第1産婦人科学教室 |
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| Journal | 核医学 |
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| Volume | 22 |
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| Number | 3 |
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| Page | 355-366 |
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| Year/Month | 1985/3 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」子宮体部癌18例に201Tlシンチグラフィを施行し, これらを病理組織学的所見および病期と比較検討した. 6例については静注直後より201Tl-Clの集積状態を核医学データ処理用ミニコンピュータに収録し, 201Tlの病巣への集積度を計測するとともに, 2例においては摘出子宮における腫瘍部と筋層部との放射能をも測定した. 摘出子宮の放射能測定では病巣には子宮筋層に比較し, ほぼ1.9倍の放射能が認められた. 6例について, 収録画像上に関心領域を設定して放射能分布を測定した結果, 病巣中心部ではバックグラウンドに比較し, 平均で約1.47倍の放射能が測定された. しかし, これらの値と組織学的所見や病期との間に関連は見られなかった. 第Ib期以上の13症例では病巣子宮に一致した陽性像が静注後早期より得られた. 第Ib, II期は均等な円形の陽性像が得られ, IV期は辺縁不整な腫大した陽性像が得られた. 第Ia期では, 5例中3例に陽性像を得たが, この3例は子宮筋腫や腺筋症を合併しており, 子宮筋腫などによる疑陽性像と考えられた. 201Tl-Clを子宮体部癌に用いることによりそのClinical efficacyはsensitivity 86.7%, specificity 0%およびaccuracy 72.2%であった. 対象がすべて体部癌であったためspecificityは0%という結果であったが逆に体部癌と確定した場合, 陽性像が得られなければ第Ia期といえるものと推定された. 以上の結果から201Tlシンチグラムによる子宮体部癌の診断は臨床上本疾患の一補助診断として, 有効な手段となりうるものと考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Uterine neoplasms, Uterine body cancer, 201Tl scintigraphy, Radionuclide diagnosis |
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| English |
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| Title | Studies on the Diagnosis of Uterine Body Cancer Using 201Tl-Chloride |
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| Subtitle | Original Articles |
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| Authors | Hiraku WATANABE |
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| Authors(kana) | |
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| Organization | First Department of Obstetrics and Gynecology, Toho University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 22 |
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| Number | 3 |
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| Page | 355-366 |
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| Year/Month | 1985/3 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] 201Tl scintigraphy was performed in 18 patients with cancer of uterine body, and the results were compared with histopathological findings. With six patients, 201Tl distribution in the pelvic cavity was registered in the minicomputer, and the time activity curve was plotted. Analysis of 201Tl distribution using ROI revealed that the radioactivity in the uterus was approximately 1.47 times as high as that in back-ground. In the removed uterus, the radioactivity in the cancer was calculated to be approximately 1.9times as high as that in the myometrium. In all 13 patients with Stage Ib or higher cancer, obvious activity in the uterus coinciding with the lesion was obtained shortly after the intravenous administration of 201Tl-Cl. Though accumulation of activity in the uterus was obtained in three of five patients with Stage Ia cancer, it was interpreted as false-positive, because myoma or adenomyosis was present in addition to cancer in these three patients, and such a complication seemed responsible for the positive result. The sensitivity, specificity and accuracy of 201Tl scintigraphy in diagnosing cancer of the uterine body were 86.7,0 and 72.2%, respectively. These results suggest that 201Tl scintigraphy is a promising diagnostic aid for cancer of the uterine body. |
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| Practice | Clinical medicine |
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| Keywords | Uterine neoplasms, Uterine body cancer, 201Tl scintigraphy, Radionuclide diagnosis |
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