| Japanese |
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| Title | 健常者のエアロゾル肺吸入シンチグラフィ |
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| Subtitle | 原著 |
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| Authors | 須井修*, 嶋津秀樹* |
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| Organization | *徳島大学医学部放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 22 |
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| Number | 3 |
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| Page | 293-298 |
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| Year/Month | 1985/3 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」肺機能検査で1秒率が70%以上を示し, 胸部X線写真で異常を認めず, 自覚的・他覚的症状のない健常者39名について, エアロゾル肺吸入シンチグラフィを施行した. 肺吸入イメージを3つのtype (type I : 均一な肺内沈着分布を示し, 中枢気道系に過剰沈着を認めない. typeII : 均一な肺内沈着分布を示すが, 中枢気道系に過剰沈着を認める. typeIII : 不均一な肺内沈着分布を示す. ) に分類し, 肺機能検査成績と比較した. typeIとtypeIIの間には, 肺機能検査成績に有意差を認めなかった. typeIIIはtypeIとtypeIIとの間に, V25のみで有意差を認め, V50/V25でも, typeIIIの3例中2例はかなりの高値を示した. typeIIIは末梢気道系の異常を表わしていると考えられ, 閉塞性肺疾患の前駆状態との関連が考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Aerosol lung inhalation scintigraphy, Lung function test, Chronic obstructive pulmonary disease, Small airway dysfunction |
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| English |
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| Title | Aerosol Lung Inhalation Scintigraphy in Normal Subjects |
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| Subtitle | Original Articles |
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| Authors | Osamu SUI, Hideki SHIMAZU |
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| Organization | Department of Radiology, School of Medicine, Tokushima University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 22 |
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| Number | 3 |
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| Page | 293-298 |
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| Year/Month | 1985/3 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] We previously reported basic and clinical evaluation of aerosol lung inhalation scintigraphy with 99mTc-millimicrosphere albumin (milli MISA) and concluded aerosol inhalation scintigraphy with 99mTc-milli MISA was useful for routine examination. But central airway deposit of aerosol particles was found in not only the patients with chronic obstructive pulmonary disease (COPD) but also normal subjects. So we performed aerosol inhalation scintigraphy in normal subjects and evaluated their scintigrams. The subjects had normal values of FEV1-0% (more than 70%) in lung function tests, no abnormal findings in chest X-ray films and no symptoms and signs. The findings of aerosol inhalation scintigrams in them were classified into 3 patterns ; type I : homogeneous distribution without central airway deposit, type II : homogeneous distribution with central airway deposit, type III : inhomogeneous distribution. These patterns were compared with lung function tests. There was no significant correlation between type I and type II in lung function tests. Type III was different from type I and type II in inhomogeneous distribution. This finding showed no correlation with %VC, FEV1.0% MMF, V50 and V50/V25, but good correlation with V25 in a maximum forced expiratory flow-volume curve. Flowvolume curve is one of the sensitive methods in early detection of COPD, so inhomogeneous distribution of type III is considered to be due to small airway dysfunction. |
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| Practice | Clinical medicine |
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| Keywords | Aerosol lung inhalation scintigraphy, Lung function test, Chronic obstructive pulmonary disease, Small airway dysfunction |
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