| Japanese |
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| Title | ガドリニウムDTPAによるNMR-CT腎動態機能検査法の試み |
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| Subtitle | 研究速報 |
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| Authors | 池平博夫*, 山根昭子*, 福田信男*, 鳥居伸一郎***, 柴田貞夫**, 松本徹*, 飯沼武*, 舘野之男* |
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| Authors(kana) | |
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| Organization | *放射線医学総合研究所臨床研究部, **化学研究部, ***慈恵会医科大学泌尿器科学教室 |
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| Journal | 核医学 |
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| Volume | 22 |
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| Number | 2 |
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| Page | 219-224 |
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| Year/Month | 1985/2 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. はじめに」核医学的腎動態機能検査には現在主として123Iや131I標識のヒプル酸塩や99mTc-DTPA (diethylenetriamine pentaacetic acid) が利用されているが, いずれによっても腎臓の断層像での経時的観察は事実上不可能である. しかし, NMR-CTを利用すれば腎臓の断層像での動態機能検査が可能となるため, 使用する薬剤と撮像法を適切に選択することによって腎動態機能の3次元的把握が可能となろう. そこで今回われわれは, 近年NMR-CT用の造影剤として高い評価を受けているGd-DTPAを使用し, 実験的にNMR-CTによる経時的腎動態機能検査を試み腎動態機能の判定に有効であると考えられたので報告する. |
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| Practice | 臨床医学：一般 |
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| Keywords | NMR-CT, Contrast agents, Gadolinium DTPA, Renogram, Renal function |
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| English |
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| Title | The Trial of the Kinetic Study for the Renal Function, Using NMR-CT by Gadolinium-DTPA |
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| Authors | Hiroo IKEHIRA*, Teruko YAMANE*, Nobuo FUKUDA*, Shinichiro TORII***, Sadao SHIBATA**, Toru MATSUMOTO*, Takeshi IINUMA*, Yukio TATENO* |
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| Authors(kana) | |
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| Organization | *Division of Clinical Research, **Division of Chemistry, National Institute of Radiological Sciences, ***Department of Urology, Jikei University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 22 |
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| Number | 2 |
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| Page | 219-224 |
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| Year/Month | 1985/2 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The kinetic in vivo study of the renal function in rabbits, using NMR image by Gd-DTPA was examined. The changes of Gd-DTPA on T1 values, followed continuously for one to two hours by animal trials, in which the effects of intravenous injection of Gd-DTPA on calculated T1 images and SR images were determined. Two different doses of Gd-DTPA were administered intravenously to rabbits. All images were obtained by the 0.1 Tesla resistive type NMR-CT imaging system. The nice pattern of renal kinetic function was got with calculated T1 (300, 1,000) images, in 0.05mmol/kg Gd-DTPA administered rabbit. The normal pattern of the NMR-CT renography was able to be separated three phase, using regional renography also, they are what we call perfusion and secretory phase, excretory phase and inversive phase. Its half-life of the excetory phase was about 20 minutes. T1 images were useful for the detection of regional renal function in the NMR tomographic image. It was concluded that the NMR renography, using stable paramagnetic metal ion chelate, Gd-DTPA as traceable intravenous contrast agents in NMR imaging would be able to use for the observation of local renal kinetic function. |
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| Practice | Clinical medicine |
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| Keywords | NMR-CT, Contrast agents, Gadolinium DTPA, Renogram, Renal function |
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