| Japanese |
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| Title | N-13アンモニアによる心筋ポジトロンCT (第2報) - 動態計測による肺, 心筋での経時的変化の検討 - |
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| Subtitle | 原著 |
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| Authors | 玉木長良*, 千田道雄*, 米倉義晴*, 児玉秋生*, 佐治英郎*, 湊小太郎*, 棚田修二*, 村田喜代史*, 鳥塚莞爾*, 小西裕**, 伴敏彦**, 神原啓文***, 河合忠一*** |
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| Authors(kana) | |
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| Organization | *京都大学医学部放射線核医学科, **心臓血管外科, ***第三内科 |
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| Journal | 核医学 |
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| Volume | 22 |
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| Number | 2 |
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| Page | 193-199 |
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| Year/Month | 1985/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」N-13アンモニア静注後の経時的変化をみるため, 15例にポジトロンCTの動態計測を行った. まず投与直後より15秒ごと3分間の初期動態計測を行い, 血液・肺・心筋の時間放射能曲線を作成, 肺のカウントの1/2になる時間 (L-T 1/2) と心筋のピークに達する時間 (M-peak) を算出した. 8例にはひき続き5分ごと30分間の後期動態計測を行った. 健常例 (3例) ではL-T 1/2が50±4.1秒, M-peakが50±18.7秒であったのに対し, 心筋梗塞例 (7例) では159±80.0秒, 99±47.9秒と延長, 僧帽弁狭窄症の1例でも300秒, 225秒と著明に延長し, 肺うっ血による肺からの排泄遅延と, 心筋への分布の遅れが示唆された. またL-T 1/2とM-peakとの間にはr=0.82の正相関がみられた. 一方後期動態計測では, 健常心筋で10-40%のカウントの増加がみられたのに対し, 梗塞部心筋では10%以上のカウントの増加を示す区城 (64%) と増加しない区域 (36%) とに2分された. N-13アンモニアポジトロンCTによる心・肺の動態計測は, 病態生理の評価に役立つと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Positron tomography, N-13 ammonia, myocardium, dynamic study, pulmonary congestion |
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| English |
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| Title | N-13 Ammonia Myocardial Positron Computed Tomography - (2) Evaluation of Serial Change in the Lung and the Myocardium - |
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| Subtitle | Original Articles |
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| Authors | Nagara TAMAKI*, Michio SENDA*, Yoshiharu YONEKURA*, Shusei KODAMA*, Hideo SAJI*, Kotaro MINATO*, Shuji TANADA*, Kiyoshi MURATA*, Kanji TORlZUKA*, Yutaka KONISHI**, Toshihiko BAN**, Hirofumi KAMBARA***, Chuichi KAWAI*** |
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| Authors(kana) | |
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| Organization | *Department of Radiology and Nuclear Medicine, **Department of Cardiovascular surgery, ***Department of Internal Medicine, Kyoto University Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 22 |
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| Number | 2 |
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| Page | 193-199 |
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| Year/Month | 1985/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] To assess temporal change of the tracer, dynamic study of cardiac positron computed tomography (PCT) was perfromed in 13 cases. Immediately after intravenous bolus injection of 10-20 mCi of N-13 labeled ammonia, sequential 15 seconds sampling was done for 3 minutes (early dynamic scan) and serial 5 minutes sampling was done for another 30 minutes (late dynamic scan) . From the early dynamic scan, the time activity curves of the blood-pool, the lung, and the myocardium were obtained to calculate halftime of the lung washout curve (L-T l/2) and peak time of the myocardium (M-peak) . From the late dynamic scan, % increase in reginoal myocardium in 30 minutes was calculated. In 3 normal cases, the blood-pool image was obtained in the first scan, and the left ventricular myocardium was visualized from the third scan. L-T 1/2 was 50+-4.1 sec and M-peak was 50+-18.7 sec. In 7 cases with myocardial infarction, early dynamic scan showed delayed appearance of the myocardium (M-peak : 99+-47.9 sec) with prolonged pulmonary uptake (L-T 1/2 : 159+-80 sec) , suggesting Pulmonary congestion. Similar results were obtained in a case with mitral stenosis (L-T 1/2 : 300 sec ; M-peak : 225 sec) . Delayed dynamic scan was performed in 3 normal cases and 5 cases with myocardial infarction. % increase in the myocardial activity was 25.1+-6.8% in normal cases, 26.1+-11.1% in normal segments in infarct cases, and 21.6+-16.9% in infarct segments. Furthermore, 5 of 14 infarct segments (36%) showed less than 10% increase while increased myocardial activity in g infarct segments (64%) , suggesting different pathophysiology in these segments. We conclude that our PCT permits serial dynamic study of the heart, which provides useful information of the tracer kinetics of the lung and the myocardium as well as of the pathophysiology of the myocardium. |
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| Practice | Clinical medicine |
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| Keywords | Positron tomography, N-13 ammonia, myocardium, dynamic study, pulmonary congestion |
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