| Japanese |
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| Title | 18FDGモデルにおける局所脳速度定数の算出とその画像化 |
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| Subtitle | 研究速報 |
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| Authors | 佐々木広*, 菅野巖*, 三浦修一*, 村上松太郎*, 高橋和弘*, 宍戸文男*, 上村和夫* |
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| Organization | *秋田県立脳血管研究センター放射線医学研究部 |
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| Journal | 核医学 |
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| Volume | 22 |
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| Number | 1 |
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| Page | 81-84 |
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| Year/Month | 1985/1 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. 緒言」14C-デオキシグルコース (DG) 法から発展した18F-フルオロデオキシグルコース (FDG) 法は, 臨床分野における局所脳ブドウ糖代謝率 (CMRG) の測定を可能にした. FDGモデルの速度定数k*1〜k*4はPhelpsらによって正常人の白質, 灰白質の値として算出された. 速度定数k*1, k*2はFDGの脳血液関門透過性, k*3, k*4は燐酸化速度を表わす値であり, 局所ごとに求めることは病態生理学的にも興味深い. 実際, 病巣部では異なった値をとると考えられる, われわれは, FDGモデルをもとにポジトロンエミッショントモグラフ (PET) による経時的な脳内18F濃度測定と動脈血中濃度測定から速度定数を逐次近似法で画素ごとに算出して画像化し, それらの値からCMRGを計算した. また, この結果をPhelpsらによる速度定数, CMRG値と比較検討した. |
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| Practice | 臨床医学：一般 |
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| Keywords | Positron emission CT, [F-18]2-fluoro-2-deoxy-D-glucose, Rate constant, Cerebral metabolic rate of glucose, Tracer kinetics |
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| English |
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| Title | Tomographic Mapping of Rate Constants of [F-18] FDG Model |
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| Authors | Hiroshi SASAKI, Iwao KANNO, Shuichi MIURA, Matsutaro MURAKAMI, Kazuhiro TAKAHASHI, Fumio SHISHIDO, Kazuo UEMURA |
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| Authors(kana) | |
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| Organization | Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels-AKITA |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 22 |
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| Number | 1 |
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| Page | 81-84 |
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| Year/Month | 1985/1 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Rate constants of kinetics of [F-18]2-fluoro-2-deoxy-D-glucose (FDG) in the brain were calculated pixel by pixel from tomographic images for 40 minutes after FDG injection and sequential plasma FDG radioactivity concentrations. Tomograms measured by HEADTOME III were five four-minute-frames followed by nine two-minute-frames. Based on the three compartment model, a time sequence of single pixel of the serial tomograms was represented as a convolution of the plasma concentration of FDG and a biexponential function. Four parameters of a biexponential function were determined pixel by pixel employing the iterative least square curve fitting. Results obtained from a normal volunteer well agreed with those reported by Phelps. Finally, images of each rate constant and cerebral metabolic rate of glucose using our rate constants were obtained. |
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| Practice | Clinical medicine |
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| Keywords | Positron emission CT, [F-18]2-fluoro-2-deoxy-D-glucose, Rate constant, Cerebral metabolic rate of glucose, Tracer kinetics |
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