| Japanese |
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| Title | 赤血球破壊動態のコンピューター解析法 |
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| Subtitle | 原著 |
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| Authors | 斉藤宏*, 小原健** |
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| Organization | *名古屋大学医学部附属病院放射線部, **放射線科 |
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| Journal | 核医学 |
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| Volume | 22 |
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| Number | 1 |
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| Page | 57-65 |
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| Year/Month | 1985/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」最小二乗法により経時的に得た血液試料のデータを処理して51Cr標識赤血球51Cr-RBC消失曲線を決定した. 上記の51Cr-RBC消失曲線に最も良く適合する曲線を (1-t/T)e-kt式で与えられる種々の曲線群の中から選んだ. そこでTは平均赤血球寿命 (MRCLS), tは標識RBCの注射後の時間 (日), eは自然対数, kは指数関数的51Cr-RBC消失率を示す. 選んだ全期間51Cr-RBC消失曲線からMRCLS, t 1/2, kを求めた. さらに, 患者の対正常人51Cr-RBC消失曲線下の面積比としての新しい指標 "相対生存率 (RSR)" を導入した. 試料の採取期間の長さとコンピューター測定した寿命の成績の精度との関係について検討した. 追跡期間 の短縮によりMRCLSは大きく変化したが, RSRは, 大部分の51Cr-RBCが指数関数的に消失している時でも, ほとんど変化しなかった. 赤血球破壊の総合的な様態はMRCLSでは必ずしも示されないが, RSRにより良く反映される. 信頼できる成績を得るために必要な追跡期間は, 初期の検査期間にすでに得られたデータをコンピューターに入力して推定できる. この方法を溶出のない標識剤を使用した例に応用すれば, 特にRBCの無差別破壊のある症例では, 用手法で得られるよりもさらに正確で分析的な情報が得られる. |
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| Practice | 臨床医学：一般 |
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| Keywords | 51Cr-RBC disappearance curve, Random destruction and aging, Relative survival rate, Erythrokinetics, Computer survey |
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| English |
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| Title | Computer Analysis on Dynamics of Red Cell Destruction |
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| Subtitle | |
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| Authors | Hiroshi SAITO*, Ken OHARA** |
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| Authors(kana) | |
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| Organization | *Division of Radiological Service, Nagoya University Hospital, **Department of Radiology, Nagoya University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 22 |
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| Number | 1 |
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| Page | 57-65 |
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| Year/Month | 1985/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Serial blood sample data were treated by the least square method and a 51Cr-RBC disappearance curve was determined. A best fit full term curve to the sampling term 51Cr-RBC disappearance curve was chosen using a computer out of the various curves given by the formula: (1-t/T)e-kt. Where, T = mean red cell life span (MRCLS), t = time (day) after the injection of labelled RBC, e = natural logarithm, k = exponential 51Cr-RBC disappearance rate. MRCLS, t 1/2, and k were obtained from the chosen full term 51Cr-RBC disappearance curve. In addition, a new index, "Relative survival rate (RSR)", as a ratio of the area under the 51Cr-RBC disappearance curve of a patient to normal was introduced. The relationship between the length of sampling term and the accuracy of the computer assayed survival data was investigated. By shortening the term of follow, MRCLS changed largely, but RSR stayed almost unchanged, even when most of 51Cr-RBC were disappearing exponentially. The general mode of red cell destruction can not always be indicated by MRCLS, but it is well reflected by RSR. The term of follow needed for obtaining reliable results can be estimated by the computer imputting data so far obtained in the early period of study. If this method is applied for the case using a labelling agent without elution, more accurate and analytical informations can be obtained than by manual method, especially in the case with random RBC destruction. |
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| Practice | Clinical medicine |
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| Keywords | 51Cr-RBC disappearance curve, Random destruction and aging, Relative survival rate, Erythrokinetics, Computer survey |
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