Japanese
Title原発性肺癌放射線治療患者におけるガリウムシンチグラフィ - 腫瘍縮小効果および予後との関係 -
Subtitle原著
Authors綾部善治*, 一矢有一*, 和田誠*, 桑原康雄*, 桂木誠*, 神宮賢一*, 松浦啓一*
Authors(kana)
Organization*九州大学医学部放射線科学教室
Journal核医学
Volume22
Number1
Page29-35
Year/Month1985/1
Article原著
Publisher日本核医学会
Abstract「要旨」放射線治療を行った原発性肺癌80例を対象として, 67Gaシンチグラフィ所見と腫瘍縮小効果および実測生存率との関連性を検討し, 治療効果推定因子としての67Gaシンチグラフィの臨床的有用性を評価した結果は次のとおりであった. 「1) 67Ga集積程度と腫瘍縮小効果との関係」治療開始時の67Ga集積が (+++)の群で縮小する症例が, また (-) 群で不変の症例が多かったが, 統計学的には有意差を認めず, 腫瘍縮小効果推定の指標には, 必ずしも成りえないと思われた. 治療開始時および終了後における67Ga集積の変化も, やはり, 指標にはならないと思われた. 「2) 67Ga集積程度と実測生存率との関係」治療開始時および終了後の67Ga集積の状況と両者間での集積の変化を実測生存率と対比検討したが関連性は見られず, 予後推定因子としての有用性は証明できなかった.
Practice臨床医学：一般
KeywordsLung cancer, 67Ga-scintigraphy, Radionuclide diagnosis, Radiation therapy
English
TitleGallium-67 Scintigraphy in Evaluation of Bronchogenic Carcinoma Treated with Radiation - Correlation with Local Effects and Prognosis -
SubtitleOriginal Articles
AuthorsZenji AYABE, Yuichi ICHIYA, Makoto WADA, Yasuo KUWABARA, Makoto KATSURAGI, Kenichi JINGU, Keiichi MATSUURA
Authors(kana)
OrganizationDepartment of Radiology, Faculty of Medicine, Kyushu University
JournalThe Japanese Journal of nuclear medicine
Volume22
Number1
Page29-35
Year/Month1985/1
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] Clinical significance of 67Ga-scintigraphy was evaluated as a prognostic factor in 80 patients with bronchogenic carcinomas treated with radiation. 67Ga-scintigraphy was performed before and after radiotherapy, and correlations between these scintigraphic findings and the changes in tumor size or observed survival rates of the patients were investigated. Degrees of 67Ga uptake in primary lesions were classified into 4 grades as +++(uptake higher than the liver), ++(uptake equal to the liver), +(uptake lower than the liver), -(no detectable uptake), and interval changes by radiotherapy were classified as "increased", "unchanged", "decreased", and "disappearing". Effects of radiation were evaluated by measurement of tumor sizes on the chest X-ray films and they were classified as "complete response", "partial response", or "no change", based on the General Rule for Clinical and Pathological Record of Lung Cancer (The Japan Lung Cancer Society, 1982). Static significances were evaluated using logrank and chi-square tests. Measurement of tumor sizes was possible in 63 cases, in which there was no statistically significant correlation between degrees of 67Ga uptake before radiotherapy and effects of radiation. Abnormal uptake of 67Ga was seen in 55 cases of 63 before radiotherapy, and there was no significant correlation between interval changes of 67Ga uptake and effects of radiation in these 55 cases. Correlations between survival rate and degrees of 67Ga uptake before and after radiotherapy were evaluated in 61 cases whose clinical stages were I-III, but they were not statistically significant. Interval changes of 67Ga uptakes by irradiation were not significantly correlated with observed survival rates.
PracticeClinical medicine
KeywordsLung cancer, 67Ga-scintigraphy, Radionuclide diagnosis, Radiation therapy

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