| Japanese |
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| Title | N-Isopropyl-P- [123I] Iodoamphetamineとガンマカメラ回転型ECTによる局所脳血流測定 |
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| Subtitle | 原著 |
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| Authors | 松田博史*, 関宏恭*, 石田博子*, 隅屋寿*, 辻志郎*, 久田欣一*, 藤井博之**, 山本信二郎**, 古林秀則***, 林実*** |
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| Authors(kana) | |
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| Organization | *金沢大学医学部核医学教室, **脳神経外科学教室, ***福井医科大学脳神経外科学教室 |
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| Journal | 核医学 |
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| Volume | 22 |
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| Number | 1 |
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| Page | 9-18 |
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| Year/Month | 1985/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」N-Isopropyl-P-[123I] Iodoamphetamine (123I-IMP) とガンマカメラ回転型ECTを用いて, 脳血管障害26例に計31回の局所脳血流測定を施行した. 血流値を次式により算出した. F=100・R・Cb/(N・A). ここでFは脳血流値 (ml/100 g/min.), Rは動脈よりの持続採血速度 (ml/min.), CbはECTより求めた脳組織の放射能濃度 (μCi/g), Nは血中の代謝産物を除いた真の123I-IMPの割合 (0.75), Aは採血した全動脈血の放射能 (μCi) である. Cbの算出にあたっては, 静注4〜5分後の再構成カウントを, 35分以後に24分かけて撮像して得られた再構成カウントから, 同時に作成した全脳の時間放射能曲線を用いて推定した. 全脳の平均血流値は11〜39 ml/100 g/min. に分布した. 9例に11回, あわせて施行した133Xe吸入法により得られた局所脳血流値と119か所で比較したところ, r=0.41 (p<0.001) と有意の相関がみられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | N-Isopropyl-p-[123I]Iodoamphetamine, rCBF, Rotating gamma camera ECT, Cerebrovascular accidents |
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| English |
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| Title | Regional Cerebral Blood Flow Measurement Using N-Isopropyl-p-[123I] Iodoamphetamine and Rotating Gamma Camera Emission Computed Tomography |
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| Subtitle | Original Articles |
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| Authors | Hiroshi MATSUDA*, Hiroyasu SEKI*, Hiroko ISHIDA*, Hisashi SUMIYA*, Shiro TSUJI*, Kinichi HISADA*, Hiroyuki FUJII**, Shinjiro YAMAMOTO**, Hidenori KOBAYASHI***, Minoru HAYASHI*** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **Department of Neurosurgery, School of Medicine, Kanazawa University, ***Department or Neurosurgery, Fukui Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 22 |
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| Number | 1 |
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| Page | 9-18 |
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| Year/Month | 1985/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Thirty-one regional cerebral blood flow (rCBF) measurements were performed on 26 patients with cerebrovascular accidents using N-Isopropyl-p-[123I]Iodoamphetamine (123I-IMP) and rotating gamma camera emission computed tomography (ECT). The equation for determining rCBF is as follows: F = 100・R・Cb/(N・A), where F is rCBF in ml/100 g/min., R is the constant withdrawal rate of arterial blood in ml/min., Cb is the brain activity concentration in μCi/g, A is the total activity (5 min.) in the withdrawal arterial whole blood in μCi and N is the fraction of A that is true tracer activity (0.75). In determining Cb at 5 min. after injection, reconstructed counts from 35 min. to 59 min. were corrected to represent those from 4 min. to 5 min. with the use of time activity curve for the entire brain immediately after injection to 30 min. Reconstructed counts of central region in tomographic image were corrected 118% of the obtained values from the result of the counting-rate ratio between peripheral and central regions of interests obtained from phantom study. Brain mean blood flow values were distributed from 11 to 39 ml/100 g/min. In 119 cortical regions obtained from 11 measurements in 9 patients, there was a significant correlation (r=0.41, p<0.001) between rCBF values obtained from 123I-IMP and rotating gamma camera ECT and those from 133Xe inhalation method. rCBF measurement using 123I-IMP and rotating gamma camera ECT is not only relatively noninvasive measurement for the entire brain but also three-dimensional evaluation. Besides, it is superior in spatial resolution and accuracy to conventional 133Xe clearance method. |
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| Practice | Clinical medicine |
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| Keywords | N-Isopropyl-p-[123I]Iodoamphetamine, rCBF, Rotating gamma camera ECT, Cerebrovascular accidents |
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