| Japanese |
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| Title | 99mTc-DTPA腎摂取率による糸球体濾過率の評価 |
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| Subtitle | 原著 |
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| Authors | 伊藤綱朗*, 竹田寛*, 豊田俊*, 前田寿登*, 北野外紀雄**, 中川毅*, 山口信夫* |
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| Organization | *三重大学医学部放射線科, **中央放射線部 |
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| Journal | 核医学 |
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| Volume | 21 |
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| Number | 12 |
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| Page | 1579-1586 |
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| Year/Month | 1984/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTc-DTPA腎摂取率によるGFRの評価について検討を加え, 以下の結果を得た. (1) 超音波法を用いて坐位にて背部より測定した腎の深さ (cm) と, 体重 (kg)/身長 (cm) 比とは, 右腎で相関係数0.849 (p<0.001), 回帰式Y=6.55X+0.66, 左腎で相関係数0.823 (p<0.001), 回帰式Y=17.05X+0.13と相関した. (2) 上で求めた回帰式を用いて, 腎の深さによるγ線吸収を補正した99mTc-DTPA腎摂取率 (%) を求め, これを内因性Ccr (ml/min) と比較検討したところ, 静注後1〜2分までの摂取率が相関係数0.925 (p<0.001) と最も良好な相関を示し, その回帰式よりGFRを腎摂取率から算出する次式が得られた. GFR (ml/min)=(1〜2分腎摂取率)×6.26+3.10 (3) この方法はGFRを短時間にかつ簡単に算出することができ, また算出されたGFRを (右腎摂取率) : (左腎摂取率) の比に配分することにより分腎GFRをも算出することができ, 腎機能検査法として臨床上非常に有用である. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-DTPA, Renal uptake ratio, Glomerular filtration rate, Attenuation correction |
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| English |
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| Title | Estimation of Glomerular Filtration Rate from Fractional Renal Uptake of 99mTc-DTPA |
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| Subtitle | Original Articles |
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| Authors | Tsunao ITO, Kan TAKEDA, Syun TOYOTA, Hisato MAEDA, Tokio KITANO, Tsuyoshi NAKAGAWA, Nobuo YAMAGUCHI |
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| Authors(kana) | |
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| Organization | Department of Radiology, Mie University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 21 |
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| Number | 12 |
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| Page | 1579-1586 |
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| Year/Month | 1984/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Glomerular filtration rate (GFR) was estimated from fractional renal uptake (FRU) of 99mDTPA using the gamma camera-digital computer system with attenuation correction for kidney depth. Forty-eight patients were studied, in whom 24 hour creatinine clearance (Ccr) were concomitantly obtained within a week of the study. A dose of 1-3 mCi of 99mTc-DTPA was rapidly injected intravenously into the patients who were prepositioned posteriorly before the gamma camera and the sequential 5 sec. frame data was stored for 20 min. in a 64×64 matrix form. Attenuation corrected total renal counts at various time intervals after tracer injection were obtained by ROI selection over renal scintigram followed by background subtraction and depth correction to compensate for gamma ray attenuation by the soft tissues. Our formula for determining kidney depth, obtained by ultrasonic scanning, is shown as follows. right kidney depth = 16.55 (weight/height) + 0.66 left kidney depth = 17.05 (weight/height) + 0.13 Attenuation corrected total renal counts was divided by injected dose measured by the gamma camera (perinjection counts minus postinjection counts in syringe) and thus FRU was calculated. FRU at 1-2 min. was best correlated with Ccr (r = 0.925, p<0.001). The formula for calculation of GFR was derived from the regression analysis. GFR = (FRU at 1-2 min.)×6.26 + 3.10 This method is highly valuable for estimating GFR rapidly and accurately. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-DTPA, Renal uptake ratio, Glomerular filtration rate, Attenuation correction |
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