Japanese
Title呼吸曲線同期133Xe肺換気イメージングおよびその位相解析法によるファンクショナルイメージ
Subtitle原著
Authors井上登美夫*
Authors(kana)
Organization*関東逓信病院放射線科
Journal核医学
Volume21
Number10
Page1237-1265
Year/Month1984/10
Article原著
Publisher日本核医学会
Abstract「要旨」心電図同期心プールイメージングの原理を応用した呼吸曲線同期133Xe肺換気イメージングより位相および振幅イメージングを試み, 位相解析法の臨床的有用性を検討した. 呼気開始のトリガ信号はピーク検出器により呼吸曲線から抽出して核医学データ処理装置に入力し, マルチゲートイメージモードにより60回分の深呼吸を加算編集し同期画像を作成した. 対象は正常者13例, COPD 24例, 肺癌5例, 肺塞栓症4例, その他20例の計66例である. 呼吸運動補正により横隔膜運動の影響は消失し, 振幅および位相分布は均一化した. 補正後の全肺位相SDは正常者群で6.3±1.5度(平均±1S.D.)に対しCOPD群は12.3±6.5度と有意に増加し(P<0.01), またFEV1.0%と有意の相関(r=0.71, p<0.001)を認めた. 振幅プロフィル曲線解析による呼吸機能異常群(n=30)に対する有病正診率は83%であった. 本法の位相解析法は不均等換気の検出に有用であり, 新しい局所肺機能検査法として日常臨床に利用しうると思われた.
Practice臨床医学：一般
Keywords133Xe ventilation imaging, Phase analysis, Fourier functional image, Gated study.
English
TitleSpirometrically Gated 133Xe Ventilation Imaging and Phase Analysis for Assessment of Regional Lung Function
SubtitleOriginal Articles
AuthorsTomio INOUE
Authors(kana)
OrganizationDepartment of Radiology, Kanto Teishin Hospital
JournalThe Japanese Journal of nuclear medicine
Volume21
Number10
Page1237-1265
Year/Month1984/10
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary]The purpose of this study is to develop the technique of performing spirometrically gated 133Xe ventilation imaging and to evaluate its clinical usefulness for the assessment of regional ventilatory function in various lung diseases. Inspiratory peaks to be used as a trigger of respiratory motion were selected by a specially designed peak detector, which analysed spirometric signals from a 133Xe gas control system. Patients rebreathed 133Xe gas through the system with constant rates signaled by a metronom. The trigger signals from the patients were recorded in a minicomputer for 60 respiratory cycles simultaneously with posterior lung images. Functional images (phase analysis images) indicating phase and amplitude of regional ventilation were constructed by the first harmonic Fourier analysis. Materials included 13 normal volunteers and patients with COPD (24), lung cancer (5), pulmonary embolism (4) and others (20). In normal controls, phase analysis images before respiratory motion correction revealed gradual decrease in amplitude from base to apex with uniform phase distribution. The amplitude and phase distribution after respiratory motion correction became even more uniform. In patients with COPD, phase analysis images showed asymmetrical and irregular amplitude distribution with non-uniform phase distribution. The standard deviation (S.D.) of phase histogram correlated well with FEV 1.0% (r=0.71, p<0.001) and down slope of flowvolume curve (r=0.55, p<0.001), and less prominently with %VC (r=0.42, p<0.01). Mean S. D. in patients with COPD (12.3 +- 6.5 degree, mean +- 1 s.d.) was significantly larger than in normal controls (6.3 +- 1.5). Amplitude profile curve analysis revealed 83% sensitivity for the detection of abnormal spirometric respiratory function test. Data aquisition and processing of present method are rapid and easy to perform. The phase analysis of the gated ventilation images should prove useful in the clinical evaluation of patients with uneven ventilation such as COPD. Especially phase images should provide new time-related information on regional ventilatory cycle, which may prove clinically useful for the detection of certain pulmonary pathology.
PracticeClinical medicine
Keywords133Xe ventilation imaging, Phase analysis, Fourier functional image, Gated study.

【全文PDF】