| Japanese |
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| Title | C15O2および11COを用いた局所肺機能検査法 |
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| Subtitle | 原著 |
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| Authors | 村田喜代史*, 藤堂義郎*, 千田道雄*, 玉木長良*, 米倉義晴*, 伊藤春海*, 藤田透*, 向井孝夫*, 湊小太郎*, 佐治英郎*, 鳥塚莞爾* |
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| Organization | *京都大学医学部核医学科放射線部 |
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| Journal | 核医学 |
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| Volume | 21 |
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| Number | 8 |
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| Page | 953-961 |
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| Year/Month | 1984/8 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」京大病院医用小型サイクロトロンより生産されるC15O2および11COを用いて, 1回吸入法により局所肺機能を検討した. C15O2の肺からの消失は肺血流に依存し, 11COの肺からの消失は肺胞膜拡散能と肺血流に依存する. この2つのガスの動態を解析することにより, 肺胞膜拡散能と肺血流を分離し, 局所的に評価することを試みた. 正常人では, 肺胞膜拡散能および肺血流の両者とも下肺野が上肺野に比して有意に大きな値を示した. 肺塞栓症などの血管障害例では病変部がhot spotとしてとらえられた. また肺線維症では, 肺胞膜拡散能は正常例に比して有意の差は認められなかったが, 肺血流は下肺野において有意の低下を示した, 肺気腫症における肺胞膜拡散能と肺血流は, 下肺野において有意の低下が認められた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Radioactive gases, Clearance rate, Pulmonary perfusion, Diffusing capacity. |
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| English |
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| Title | Regional Pulmonary Function Assessed by C15O2 and 11CO Inhalation |
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| Subtitle | Original Articles |
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| Authors | Kiyoshi MURATA, Giro TODO, Michio SENDA, Nagara TAMAKI, Yoshiharu YONEKURA, Harumi ITOH, Toru FUJITA, Takao MUKAI, Kotaro MINATO, Hidero SAJI, Kanji TORIZUKA |
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| Organization | Department of Radiology, and Nuclear Medicine, Kyoto University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 21 |
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| Number | 8 |
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| Page | 953-961 |
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| Year/Month | 1984/8 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Regional pulmonary blood flow and diffusion were measured using positron imaging of C15O2 and 11CO. Blood flow was estimated from the monoexponential clearance rate of C15O2. The alveolar transfer rate (diffusion) was calculated by the clearance curve of 11CO and the clearance rate of C15O2 using a non-linear least-aquares fitting method. Six normal volunteers and nineteen patients with various pulmonary disorders underwent C15O2 and 11CO inhalation. In normal subjects, the alveolar transfer rates and blood flow in the lower lung field were significantly greater than those in the upper lung field. Pulmonary emboli were demonstrated as "hot spots" on serial positron images. In patients with interstitial fibrosis, the alveolar transfer rate was not different from that in normal subjects. However, blood flow was significantly lower than in the normals. In patients with pulmonary emphysema, the alveolar transfer rate was lower suggesting the decreased alveolar capillary beds. Thus, dynamic study using C15O2 and 11CO inhalation provides regional blood flow and diffusion, which may permit the differentiation of various pulmonary disorders. |
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| Practice | Clinical medicine |
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| Keywords | Radioactive gases, Clearance rate, Pulmonary perfusion, Diffusing capacity. |
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