| Japanese |
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| Title | 鉄剤による67Ga腫瘍イメージの増強について |
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| Subtitle | 原著 |
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| Authors | 東与光*, 古川恵司*, 若尾博美*, 小林雅人*, 大塚均* |
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| Organization | *神奈川歯科大学放射線学教室 |
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| Journal | 核医学 |
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| Volume | 21 |
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| Number | 7 |
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| Page | 791-798 |
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| Year/Month | 1984/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」鉄とガリウムが拮抗的であることから, 鉄剤あるいは鉄キレート剤を67Ga注射の前後に注射して, 67Gaの腫瘍イメージを増強する動物実験の報告は, 今までに少なくない. 今回, 著者らは, 腫瘍に67Gaが十分に取り込まれた後に鉄剤を投与して, 血中および正常組織から67Gaを排泄し, 腫瘍イメージの増強の可能性を検討した. 実験には, 担癌マウスおよび担癌家兎を用い, 臨床例では, 肺癌の症例について67Gaを注射して24〜72時間後に鉄剤のFesinを静注して, 腫瘍イメージを対照と比較した. その結果, 動物実験および臨床例で67Gaの腫瘍イメージは, やや増強されることがわかった. しかし, 鉄剤の投与によって, 67Gaは腫瘍自身からも排泄するために, 期待したほどの良い腫瘍イメージは得られなかった. |
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| Practice | 臨床医学：一般 |
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| Keywords | Ga-67 tumor image, iron-loading, lung cancer, tumor enhancement. |
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| English |
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| Title | Relative Tumor Enhancement of Ga-67 Uptake by Iron-loading |
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| Subtitle | Original Articles |
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| Authors | Tomomitsu HIGASHI, Keiji FURUKAWA, Hiromi WAKAO, Masato KOBAYASHI, Hitoshi OTSUKA |
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| Authors(kana) | |
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| Organization | Department of Radiology, Kanagawa Dental College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 21 |
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| Number | 7 |
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| Page | 791-798 |
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| Year/Month | 1984/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]In 1979 Larson reported that uptake of Ga-67 in tumor cells preceded by binding of the Ga-67 to transferrin. Since that time there have been many reports concerning the change in Ga-67 accumulation in transplantable rodent tumor by administration of iron before and after Ga-67 injection. This study was undertaken in attempt to discern what changes were produced in Ga-67 images of malignant tumors both experimentally and clinically when iron was administered 24 to 72 hours after Ga-67 injection. Experimentally, it was observed that the tumor to blood ratio of Ga-67 in tumor-bearing mice by iron-loading at 24 hours after Ga-67 injection was several times greater than that of Ga-67 alone. In clinical trials, fesin (saccharated ferric oxide) was given intravenously at 48 or 72 hours post Ga-67 administration. This allowed time for adequate accumulation in tumor tissue. It was found that fesin accelerated the excretion of Ga-67 from the blood and non-tumor tissue and improved Ga-67 tumor-to-non tumor ratios in patients with lung cancer. |
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| Practice | Clinical medicine |
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| Keywords | Ga-67 tumor image, iron-loading, lung cancer, tumor enhancement. |
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