| Japanese |
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| Title | 小児における血清および髄液β2-microglobulin値の臨床的意義 |
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| Subtitle | 原著 |
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| Authors | 矢野正幸*1, 鈴木崇代*2, 殿内力*3, 瀬戸嗣郎*4, 平尾敬男*4, 高橋昌里*5, 三間屋純一*3, 中村孝*6 |
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| Authors(kana) | |
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| Organization | *1静岡県立こども病院核医学, *2薬剤部, *3血液・腫瘍科, *4感染・免疫・アレルギー科, *5腎臓内科, *6内科 |
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| Journal | 核医学 |
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| Volume | 21 |
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| Number | 6 |
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| Page | 705-712 |
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| Year/Month | 1984/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」健康小児における年齢と血清β2-MG濃度の推移を検討し, 更に各種疾患における血清β2-MG濃度および髄液中β2-MG濃度を測定した. その結果, 健康小児では生後加齢とともに血清β2-MG濃度は漸減し, 12歳以降で成人値に達した. 今回求めた正常値を基準に各種疾患における血清β2-MG濃度を測定すると, 患児の臨床状態を良く反映する結果が得られた. また悪性腫瘍患児において髄液/血清β2-MG濃度比を測定したところ, 髄液の細胞学的検索の結果と良く一致しており, 髄液中に異常細胞が出現する以前に髄膜浸潤の有無を確認することの可能性が示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Radioimmunoassay, β2-microglobulin, Healthy children, Mucocutaneous lymphonode syndrome, Cerebrospinal fluid. |
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| English |
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| Title | Clinical Significance of β2-microglobulin in Serum and Cerebrospinal Fluid (CSF) in Childhood |
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| Subtitle | Original Articles |
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| Authors | Masayuki YANO*1, Takayo SUZUKI*2, Tsutomu TONOUCHI*3, Shirou SETO*4, Takao HIRAO*4, Shouri TAKAHASHI*5, Junichi MIMAYA*3, Takashi NAKAMURA*6 |
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| Authors(kana) | |
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| Organization | *1Division of Nuclear Medicine, *2Department of Pharmacy, *3Division of Haematology and Oncology, *4Division of Allergy, Immunology and Infectious Disease, *5Division of Nephrology, *6Division of Internal Medicine, Shizuoka Children's Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 21 |
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| Number | 6 |
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| Page | 705-712 |
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| Year/Month | 1984/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Beta 2-microglobulin (β2-MG) concentration in serum and cerebrospinal fluid (CSF) under various diseases, and the concentration in serum with relation to the age of healthy children were investigated. The normal value in serum decreased with the age of children and reached the level of adults after 12 years old. Comparing with the normal level, the serum β2-MG concentration in patients with disease reflected well their clinical findings. In children bearing malignant tumor, the ratio of β2-MG concentration in CSF to that in serum showed good coincidence with the result of CSF cytodiagnosis. Therefore, the possibility for confirmation of meningo-infiltration prior to the apperanse of abnormal cells in CSF was suggested. |
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| Practice | Clinical medicine |
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| Keywords | Radioimmunoassay, β2-microglobulin, Healthy children, Mucocutaneous lymphonode syndrome, Cerebrospinal fluid. |
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