| Japanese |
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| Title | バセドウ病の131I治療後に発見された甲状腺結節についての検討 |
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| Subtitle | 原著 |
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| Authors | 海瀬和郎*, 斉藤慎太郎*, 桜田俊郎*, 海瀬信子*, 吉田克己*, 山本蒔子*, 深沢洋*, 野村隆*, 鈴木道子*, 板垣洋*, 吉永馨* |
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| Authors(kana) | |
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| Organization | *東北大学医学部第二内科 |
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| Journal | 核医学 |
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| Volume | 21 |
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| Number | 3 |
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| Page | 215-219 |
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| Year/Month | 1984/3 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 昭和33年から同49年までの16年間に, 131I治療を受けたバセドウ病447例のうち, 8例にその後に甲状腺結節が発見された. これら8例はすべて手術を受け, その組織診断は, 乳頭癌3例および良性結節5例であった. 良性結節の内訳は, 慢性甲状腺炎1例, 腺腫様甲状腺腫2例, 慢性甲状腺炎と腺腫様甲状腺腫の合併例1例および腺腫1例であった. 131I治療から結節発見までの期間は, 甲状腺癌の3例では平均13.3年で, 良性結節の例の平均5.8年より長かった. この両者の間では, 131I治療時の年齢および投与量には差を認めなかった. 結節発見時の甲状腺機能では, 癌の2例および良性結節の2例でTSHが高値であった. また, 131I治療14年後に見い出された他の1例の癌では, 一時euthyroidであった甲状腺機能は再び亢進していた. |
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| Practice | 臨床医学：一般 |
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| Keywords | thyroid cancer, thyroid nodule, radioiodine therapy, thyroid function. |
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| English |
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| Title | Thyroid Nodule after Radioiodine (131I) Therapy for Graves' Disease |
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| Authors | Kazuro KAISE*, Shintaro SAITO*, Toshiro SAKURADA*, Nobuko KAISE*, Katsumi YOSHIDA*, Makiko YAMAMOTO*, Hiroshi FUKASAWA*, Takashi NOMURA*, Michiko SUZUKI*, Hiroshi ITAGAKI*, Kaoru YOSHINAFA* |
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| Authors(kana) | |
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| Organization | *Second Department of Internal Medicine, Tohoku University, School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 21 |
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| Number | 3 |
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| Page | 215-219 |
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| Year/Month | 1984/3 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Among 447 patients treated with radioiodine (131I) for thyrotoxicosis in our clinic from 1958 to 1974, there were 8 patients (1 male and 7 female) with thyroid nodules which appeared 2.5 to 21 years after the 131I administration. In 4 out of 8 patients, thyroid nodules were detected 9 to 16.8 years after 131I-therapy, but there was no abnormality in their thyroid gland when they were checked 1 to 10 years before the appearance of the nodules. Surgical resection of these nodules revealed 3 thyroid cancer (papillary carcinoma) and 5 benign thyroid nodules including an adenoma, a chronic thyroiditis, 2 adenomatous goitors, an adenomatous goitor with chronic thyroiditis. Mean interval after 131I-therapy was 13.3 years in patients with thyroid cancer and 5.8 years in those with benign thyroid nodule. There were no differences in age at 131I-therapy and in dose of 131I between patients with thyroid cancer and those with benign thyroid nodule. The first patient with thyroid cancer had high serum TSH, low serum T4 and low serum T3, the second high TSH with low T4 and normal T3, and the third was thyrotoxic with increased T4 and T3. Elevated TSH with or without low T4 and T3 was found in two patients with benign thyroid nodule. The rest had normal thyroid function. |
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| Practice | Clinical medicine |
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| Keywords | thyroid cancer, thyroid nodule, radioiodine therapy, thyroid function. |
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