| Japanese |
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| Title | びまん性肝疾患におけるTc-99m N-pyridoxyl-5-methyltryptophan (Tc-99m PMT) による定量的肝胆道機能解析法 |
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| Subtitle | 研究速報 |
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| Authors | 楢林勇*, 石堂伸夫*, 杉村和朗*, 鍋嶋康司*, 松尾導昌*, 木村修治*, 梶田明義** |
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| Authors(kana) | |
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| Organization | *神戸大学医学部放射線医学教室, **大阪府立成人病センター放射線科 |
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| Journal | 核医学 |
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| Volume | 21 |
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| Number | 1 |
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| Page | 41-44 |
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| Year/Month | 1984/1 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. 緒言」 テクネチウム-N-ピリドキシル-5-メチルトリプトファン (以下99mTc-PMTと略す) の肝摂取, 移送, 排泄についての動的情報を数学的手段の導入とコンピュータの導入により, 体内動態モデルを設定して定量的に肝胆道機能解析法を試みた. 「II. 方法」 99mTc-PMT 3.75 mCi静注後, シンチカメラ画像を核医学データ処理装置東芝GMS 80-Aへ入力した. 測定は10秒ごと60分間である. コンパートメントモデルはFig. 1に示すごとく, 軟部組織, 心, 肝, 肝内胆管に設定してそれぞれの放射能計数率 (C1, C2, C3, C4) と分布容積 (V1, V2, V3, V4) を考慮した理論式を構成した. この線量, 時間, 関数の一般式を数学的に解いた. 心臓と肝に関心領域 (ROIと略す) を設定し, それらの時間放射能曲線を得た. |
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| Practice | 臨床医学：一般 |
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| Keywords | kinetic study, Tc-99m PMT, diffuse parenchymal liver disease. |
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| English |
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| Title | Quantitative Analysis by Digital Computer of Tc-99m PMT Hepatogram in Diffuse Parenchymal Liver Diseases |
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| Subtitle | Rapid Communication |
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| Authors | Isamu NARABAYASHI*, Nobuo ISHIDO*, Kazuro SUGIMURA*, Koji NABESHIMA*, Michimasa MATSUO*, Shuji KIMURA*, Akiyoshi KAJITA** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Kobe University School of Medicine, **Department of Radiology, The Center for Adult Diseases |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 21 |
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| Number | 1 |
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| Page | 41-44 |
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| Year/Month | 1984/1 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Tc-99m PMT hepatograms were analyzed to provide information about the liver and bile duct. Calculations were based on a 4 compartmental model and included corrections for blood, tissue liver and bile backgrounds. The time-activity curves for Tc-99m PMT in the cardiac region were described as the sum of 2 exponential functions, while curves for the hepatic region were described as the sum of 3 exponential components. The measured hepatograms were compared with simulated hepatograms and good agreement between the two curves showed that the compartment model adequately described the blood and bile activities in vivo. Prior to the development of this compartmental model, no useful kinetic model had been found which could satisfactorily explain the time-activity curves. Experience in human studies proves this method to be accurate in determining the rate constants for hepatobiliary transport of Tc-99m PMT. |
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| Practice | Clinical medicine |
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| Keywords | kinetic study, Tc-99m PMT, diffuse parenchymal liver disease. |
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