| Japanese |
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| Title | インビボ標識99mTc-赤血球経直腸門脈シンチグラフィによる門脈循環の検討 |
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| Subtitle | 原著 |
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| Authors | 塩味正雄* |
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| Organization | *埼玉医科大学第三内科 |
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| Journal | 核医学 |
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| Volume | 21 |
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| Number | 1 |
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| Page | 7-18 |
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| Year/Month | 1984/1 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」肝疾患時の門脈循環動態を99mTc-標識赤血球 (99mTc-RBC) 経直腸門脈シンチグラフィによって検討した. 放射性薬剤注入後のシンチグラム上の, 肝臓, 心臓画像出現順序および肝臓, 心臓の関心領域より得た時間放射能曲線から算定した肝/心初期勾配比に関しては, 従来の報告とほぼ近似した結果が得られたが, さらに, 本法によって腹部血管造影にて証明された肝外静脈瘤がシンチグラム上放射性薬剤の高集積部 (hot spot) として明確に描出されることが判明した. また, 99mTcO4-を99mTc-標識赤血球として, 放射性薬剤の血管外への移行を少なくすることにより, 本法が腸管よりの吸収率をよく反映するものと考え, 99mTcO4-の吸収指標に心臓領域の時間放射能曲線より得たT 1/2を用いた結果, 対照群のT 1/2は, 245±98 sec. 慢性活動性肝炎群, 421±96 sec. 肝硬変群, 542±225 secの値を得た. すなわち, T 1/2は対照群に対し両疾患群に有意な遅れを認めた. 以上より, 本法は肝疾患の門脈循環動態を評価するうえできわめて有効な方法であるといえる. |
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| Practice | 臨床医学：一般 |
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| Keywords | portal circulation, per-rectal portal scintigraphy, portal shunt, in vivo labeled 99mTc-RBC. |
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| English |
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| Title | Evaluation of the Portal Circulation by Per-rectal Portal Scintigraphy with in Vivo Labeled 99mTc-RBC |
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| Subtitle | Original Articles |
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| Authors | Masao SHIOMI |
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| Organization | Third Department of Internal Medicine, Saitama Medical School Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 21 |
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| Number | 1 |
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| Page | 7-18 |
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| Year/Month | 1984/1 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Changes in the portal circulation in liver disease were studied by per-rectal portal scintigraphy using in vivo labeled 99mTc-RBC. With regard to the order of images of the liver and the heart appearing on the scintigram after infusion of tracer and to the liver-to-heart ratio in early slope calculated from the time-activity curve obtained from the regions of interest of the liver and heart, result almost the same as those conventionally reported were obtained. It was revealed, in addition, that the present method made it possible to outline clearly the extrahepatic varix demonstrated by angiography of the abdomen as a site of high accumulation of tracer (hot spot) on the scintigram. This method using 99mTcO4- as alabel for the red blood cells reflects the rate of absorption from the intestinal tract by suppressing the migration of tracer outside the blood vessels. The T 1/2 obtained from the time-activity curve of the region of the heart was used as an index of absorption of 99mTcO4-. The T 1/2 of control group, the chronic active hepatitis group and the liver cirrhosis group were 245+-98 sec, 421+-96 sec and 542+-225 sec, respectively. Suggesting that T 1/2 of both affected groups were significantly longer than that of control group. Finally, this method was effective for evaluating changes in the portal circulation in liver disease. |
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| Practice | Clinical medicine |
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| Keywords | portal circulation, per-rectal portal scintigraphy, portal shunt, in vivo labeled 99mTc-RBC. |
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