| Japanese |
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| Title | 骨髄内病変のNMRによる診断の基礎 |
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| Subtitle | 短報 |
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| Authors | 村中明*, 大塚信昭*, 斉藤純一**, 柳元真一*, 友光達志*, 伊藤安彦**, 森田陸司* |
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| Authors(kana) | |
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| Organization | *川崎医科大学核医学教室, **福島医科大学核医学教室 |
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| Journal | 核医学 |
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| Volume | 20 |
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| Number | 9 |
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| Page | 1349-1354 |
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| Year/Month | 1983/11 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. 緒言」 骨髄内病変の画像診断には, 放射性コロイドや111InCl3などを用いた核医学的手段が用いられてきたが, 骨髄への集積が低率などの理由から十分な成果が得られていない. 一方, 核磁気共鳴 (nuclear magnetic resonance, NMR) 信号の画像化が実用の段階にはいり特に緩和時間T1, T2の測定およびその画像化は今までの映像法にはない生体の物理化学的状態の情報を提供するものと期待されている. プロトンのNMRイメージングにおいては, 骨は水分が少なくNMR信号が弱いこと, 断層面が自由に選択でき脊髄を長軸方向に抽出することが可能なことなどから, 骨髄内病変を検出するのに適しているものと考えられる. 著者らはこの点に着目し, 家兎の骨髄腔内腫瘍のT1, T2の測定あるいは放血や抗癌剤投与による骨髄の変化とT1, T2の変化を測定することにより, 骨髄内病変におけるNMRイメージングの有用性を基礎的に検討した. |
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| Practice | 臨床医学：一般 |
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| Keywords | Bone marrow diseases, NMR imaging, Spin-lattice (T1) relaxation time, Spin-spin (T2) relaxation time |
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| English |
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| Title | Basic Studies on Bone Marrow Diseases Using NMR |
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| Subtitle | |
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| Authors | Akira MURANAKA*, Nobuaki OTSUKA*, Junichi SAITO**, Shinichi YANAGIMOTO*, Tatsushi TOMOMITSU*, Yasuhiko ITO**, Rikushi MORITA* |
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| Authors(kana) | |
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| Organization | *Division of Nuclear Medicine Kawasaki Medical School, **Department of Nuclear Medicine Fukushima Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 20 |
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| Number | 9 |
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| Page | 1349-1354 |
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| Year/Month | 1983/11 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] In order to know usefulness of NMR imaging in bone marrow diseases, spin-lattice relaxation time (T1) and spin-spin relaxation time (T2) in intramedullary transplanted VX-2-rabbits were measured. Effects of blood loss and administration of anticancer agents on T1 and T2 values were also studied. Proton-NMR spectra in normal bone marrow tissues separated into two peaks originated from H2O and CH2-chains. T1 and T2 valuse in two peaks were markedly different. Content of fatty marrow was variable in individuality and localization. These anatomical and biochemical features suggest us the necessity to evaluate T1 and T2 in each peak separatedly for construction of NMR images. As for T1 and T2 in H2O-peaks, T1 in VX-2 was about 1.3 times as much as that of normal bone marrow tissues, while T2 was about 1.7 times. Blood loss (stimulation) and administratrion of Mitomycin C (suppression) affected T1 and T2 in bone marrow. Namely, these prodedures caused increases of T1 and T2 and the values were between the values for normal marrow and tumor. NMR-CT might be useful for diagnostic bone marrow imaging supported by pathological and biochemical stand points. |
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| Practice | Clinical medicine |
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| Keywords | Bone marrow diseases, NMR imaging, Spin-lattice (T1) relaxation time, Spin-spin (T2) relaxation time |
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