| Japanese |
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| Title | 狭心症患者における左室のAsynchronous fillingについて - マルチプルゲート法による検討 - |
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| Subtitle | 原著 |
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| Authors | 山岸隆*, 尾崎正治*, 池園徹*, 清水達朗*, 古谷雄司*, 小川宏*, 松田泰雄*, 久萬田俊明*, 楠川禮造*, 西上啓二**, 松浦昭人**, 有馬暁光** |
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| Authors(kana) | |
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| Organization | *山口大学医学部第二内科, **町立大和病院 |
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| Journal | 核医学 |
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| Volume | 20 |
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| Number | 9 |
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| Page | 1263-1271 |
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| Year/Month | 1983/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 虚血心における左室の拡張期流入障害に及ぼす左室局所流入の影響について検討するため, 健常者22名および冠状動脈前下行枝起始部のみ有意な病変を有し, 心筋梗塞の既往のない狭心症者22名を対象に, 安静時99mTc心プール検査を行った. 左室を拡張末期像の面積重心を中心に4分画し, 中隔部, 心尖部および側壁部につきTime-activity curveとその一次微分曲線を作成し, peak filling rate (PFR) と左室全体の収縮末期より各局所のPFRまでの時間 (Time to peak filling rate (TPFR) ) について, 左室全体および各局所につき検討した. 狭心症群において病変冠動脈による灌流領域である心尖部でPFRの軽度低下はみられたが, 中隔部では健常群, 狭心症群間に有意差はみられなかった. またTPFRは狭心症群においてこれらの領域で著明に延長した. 一方, 正常灌流領域である側壁部ではPFR, TPFRともに両群間に有意差はなかった. この結果は, 正常灌流領域と障害灌流領域との間に拡張期流入の非協調性 (asynchrony) が存在し, それが左室全体のPFRの低下およびTPFRの延長を来す左室流入障害の原因となると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | multiple gated blood pool imaging, angina pectois, asynchronous diastolic filling |
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| English |
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| Title | Asynchronous Left Ventricular Diastolic Filling at Rest in Patients with Angina Pectoris : Assessment by Multiple Gated Blood Pool Imaging |
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| Subtitle | Original Articles |
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| Authors | Takashi YAMAGISHI*, Masaharu OZAKI*, Tohru IKEZONO*, Tatsuro SHIMIZU*, Yuji FURUTANI*, Hiroshi OGAWA*, Yasuo MATSUDA*, Toshiaki KUMADA*, Reizo KUSUKAWA*, Keiji NISHIUE**, Akito MATSUURA**, Akimitsu ARIMA** |
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| Authors(kana) | |
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| Organization | *Department of Internal Medicine, Yamaguchi University School of Medicine, **Yamato Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 20 |
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| Number | 9 |
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| Page | 1263-1271 |
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| Year/Month | 1983/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Diastolic filling of LV has been reported to be impaired at rest in many patients (pts) with angina pectoris (G II) . However, little is known regarding the relation between global and regional filling. To study this, we conducted a resting ECG-gated pool study in the modified LAO view in 22 normal subjects (G I) , and 22 G II pts with significant stenosis (>75%) of only the main LAD. No pts had a previous myocardial infarction. A computer program subdivided the end-diastolic image of LV into 4 regions (Basal, Septal (SEP) , Apical (AX) and Lateral (LAT) ) at the geometric center. The time-activity curves and its first derivatives of global LV (GLB) , SEP, AX, and LAT were computed. In regions perfused by involved vessel (AX and SEP) , normalized peak filling rate (PRF) were slightly reduced in Ax, but not in SEP. The time to PFR (TPFR) , measured from global end-systole to regional PFR, were significantly prolonged in SEP (p<0.001) and in AX (p<0.001) . In contrast, in normally perfused region (LAT) , there were no significant difference in PFR and in TPFR between G I and G II pts. This indicates the existence of asynchronous filling in the different regions of LV in G II pts. Thus in pts with angina pectoris, asynchronous diastolic filling occurs in the different regions of LV due to the filling disturbance on the affected side, which may cause impairement of the diastolic filling of the global LV. |
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| Practice | Clinical medicine |
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| Keywords | multiple gated blood pool imaging, angina pectois, asynchronous diastolic filling |
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