Japanese
Title肥大心における拡張期指標の有用性 - 99mTc-心プールイメージングによる検討 -
Subtitle原著
Authors成田充啓*, 栗原正*, 村野謙一*, 宇佐美暢久*, 本田稔**, 金尾啓右**
Authors(kana)
Organization*住友病院内科, **アイソトープ室
Journal核医学
Volume20
Number8
Page1133-1144
Year/Month1983/9
Article原著
Publisher日本核医学会
Abstract「要旨」99mTc multigate心プールイメージングを, 安静時に, 健常20例, 肥大性心筋症 (HCM) 20例, 高血圧性心肥大 (HT) 10例で施行, 左室容積曲線より, 収縮, 拡張期指標を求め, その有用性を検討した. 収縮期指標は左室駆出率 (LVEF) , 収縮早期1/3における平均駆出速度 (1/3 ERmean) を, 拡張期指標は, 拡張早期1/3における左室平均充満速度 (1/3 FRmean) , 拡張期最大充満速度 (FRmax) を求めた. LVEFはHCMで健常群より, 1/3 ERmeanはHCMで健常群, HTより有意に高値を示した. 拡張期指標のうちFRmaxは3群間で有意差をみなかったが, 1/3 FRmeanはHCM, HT両群で健常群より有意に低く, HCM 20例中13例, HT 10例中8例が異常値 (<1.56 sec-1) を示した. またHCM群でNYHA Class II or III の症例は, Class I の症例に比し, 1/3 FRmeanが有意に低かった. Mモード心エコーでえた左室壁厚と1/3 FRmean/1/3 ERmeanの間には, r=-0.77の高度な相関が存在した. 以上より拡張期指標である1/3 FRmeanは, 肥大心の存在, その機能障害を客観的に評価する上で有用と考えられた.
Practice臨床医学：一般
Keywordsleft ventricular hypertrophy, diastolic phase index, mean first third filling rate, gated blood pool imaging
English
TitleUsefulness of Diastolic Phase Index by Gated Cardiac Blood Pool Imaging in Patients with Left Ventricular Hypertrophy
Subtitle
AuthorsMichihiro NARITA*, Tadashi KURIHARA*, Kenichi MURANO*, Masahisa USAMI*, Minoru HONDA**, Keisuke KANAO**
Authors(kana)
Organization*Department of Internal Medicine, Sumitomo Hospital, **Devision of Nuclear Medicine, Sumitomo Hospital
JournalThe Japanese Journal of nuclear medicine
Volume20
Number8
Page1133-1144
Year/Month1983/9
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] To assess the felt ventricular (LV) diastolic filling rate in patients with LV hypertrophy, we analyzed LV time activity curves obtained from gated cardiac blood pool imaging. Gated cardiac blood pool imaging with Tc-99m were obtained at rest in 20 normal subjects, 20 patients with hypertrophic cardiomyopathy (HCM) and 10 patients with hypertensive hypertrophy (HT) . As systolic indices we obtained LV ejection fraction (EF) and mean first third ejection rate (1/3 ERmean) . And as diastolic indices, mean filling rate during the first third of diastole (1/3 FRmean) and maximal filling rate during the whole diastole (FRmax) were calculated. LVEF and 1/3 ERmean in patients with HT were not different significantly from normal, but those in patients with HCM were significantly greater than normal (p<0.01) , besides 1/3 ERmean in patients with HCM was greater than that in HT (p<0.01) . Among diastolic phase indices, FRmax was not different significantly between 3 groups, but 1/3 FRmean in HCM (1.47+-0.30 sec-1) and HT (1.34+-0.38 sec-1) was significantly lower (p<0.001) than normal (2.10+-0.27 sec-1) . Abnormal 1/3 FRmean (<1.56 sec-1) was found in 65% of HCM and 80% of HT. Besides, in patients with HCM, 10 patients who had exertional dyspnea and anginal chest pain (NYHA Class II or III) showed significantly lower 1/3 FRmean values than 10 patients without symptoms (1.25+-0.15 sec-1 vs 1.70+-0.25 sec-1, p<0.01) . 1/3 FRmean did not correlated well with LV wall thickness (summation of septal and posterior wall thickness) which was measured by ecohocardiography. But the ratio of 1/3 FRmean to 1/3 ERmean correlated well (r=-0.77, p<0.01) with wall thickness in patients with LV hypertrophy. In conclusion, early diastolic phase index (1/3 FRmean) was useful for the detection of LV hypertrophy and to evaluate functional impairment in patients with HCM.
PracticeClinical medicine
Keywordsleft ventricular hypertrophy, diastolic phase index, mean first third filling rate, gated blood pool imaging

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