| Japanese |
|---|
| Title | 99mTc-ミリマイクロスフェアによるエアロゾル肺吸入スキャン - 基礎的検討と臨床評価 - |
|---|
| Subtitle | 原著 |
|---|
| Authors | 須井修*†, 分校久志*, 油野民雄*, 大口学*, 久田欣一* |
|---|
| Authors(kana) | |
|---|
| Organization | *金沢大学医学部核医学教室, †現徳島大学医学部附属病院放射線科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 20 |
|---|
| Number | 8 |
|---|
| Page | 1121-1131 |
|---|
| Year/Month | 1983/9 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」99mTc-ミリマイクロスフェア (milli MISA) によるエアロゾル肺吸入スキャンについて, 基礎的検討および臨床的評価を行った. エアロゾルの粒子径は, キャリアガスのO2流量を6 l/min, 8 l/min, 10 l/minと変化させた場合, それぞれ1.75±1.07μ, 1.87±1.18μ, 2.34±1.55μとなり, O2流量は6 l/minが適当であった. 健常者では安静呼吸時, エアロゾルの肺内沈着量は吸入時間に比例し, またスキャン像では, 過剰沈着はみられず, 肺に均一に分布した. 過呼吸状態にした場合, 中枢気道系に過剰沈着が認められ, 末梢の沈着分布も不均一になる傾向があった. 臨床的には慢性閉塞性肺疾患, 肺血管性病変, 肺腫瘍などの疾患で, 換気分布, 気道の開通性を評価するのに有用であった. milli MISAによる肺吸入スキャンは, 常時, 手軽に施行でき, 基礎的にも臨床的にも, ルーチン検査として有用と考えられた. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | millimicrosphere albumin, aerosol lung inhalation scan, ventilation, aerodynamic change |
|---|
| English |
|---|
| Title | Aerosol lung inhalation scan with 99mTc-millimicrospheres - Basic and clinical evaluation - |
|---|
| Subtitle | |
|---|
| Authors | Osamu SUI*, Hisashi BUNKO**, Tamio ABURANO**, Manabu OGUCHI**, Kinichi HISADA** |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Radiology, School of Medicine, Tokushima University, **Department of Nuclear Medicine, School of Medicine, Kanazawa University |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 20 |
|---|
| Number | 8 |
|---|
| Page | 1121-1131 |
|---|
| Year/Month | 1983/9 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] We performed basic and clinical evaluation of aerosol lung inhalation scan with 99mTc-millimicrospheres (milli MISA) . The mean diameter of aerosol particles was increased when the flow rate of carrier O2 gas was increased. Ninety percent of the particle was less than 3μ in diameter when the flow rate of O2 gas was 6l/min and this flow rate was adequate to routine study. In normal subjects, the amount of radioactivity deposited in the lung was proportional to the inhaled time and it was about 1% of the original activity in the nebulizer after 10 minutes tidal breating. Aerosol deposition in the lung was homogeneous and no central airway deposit was seen. But when the respiratory rate was increased, central airway deposit and decreased peripheral penetration was observed. We classified the findings of the aerosol inhalation images in COPD according to the Suzuki's, method. This criteria of aerosol scan was compared with the lung function tests and showed good correlation with FEV 1.0%. In pulmonary vascular disease, ventilationperfusion mismatch was observed in all 8 cases. In lung cancer, aerosol inhalation scan was also useful for follow-up examination after radiotherapy. Excessive deposition of upper airways in these patients was correlated well with the bronchoscopic findings, and was thought to be due to narrowing of trachea and bronchi. We concluded that aerosol lung inhalation scan with 99mTc-milliMISA was easy to perform and was useful for routine examination. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | millimicrosphere albumin, aerosol lung inhalation scan, ventilation, aerodynamic change |
|---|