| Japanese |
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| Title | 123I-orthoiodo hippurate (OIH) による有効腎血漿流量 (ERPF) 測定の有用性 |
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| Subtitle | 原著 |
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| Authors | 高山輝彦*, 多田明*, 油野民雄*, 利波紀久*, 久田欣一*, 山田正人** |
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| Organization | *金沢大学医学部核医学教室, **附属病院アイソトープ部 |
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| Journal | 核医学 |
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| Volume | 20 |
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| Number | 6 |
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| Page | 841-847 |
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| Year/Month | 1983/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」123I-orthoiodo hippurate (123I-OIH) を用いて連続腎シンチグラムを撮像し, Tauxeらの方法に基づいてEffective renal plasma flow (ERPF) を算出した. 1) 123I-OIHによるERPFとpara-amino-hippurate (PAH) によるERPFは, 相関係数r=0.77 (p<0.01) 回帰式y=0.87x+65で相関した. 2) 静注直後より3分までの累積計数の左右比によってERPFを配分して得た分腎ERPFは, 分腎機能の評価に有効である. 3) 従来のレノグラムの標準型, 遅延型では分腎ERPFが100ml/min以上であったが, 機能低下型では100ml/min以下であった. 4) 皮質部レノグラムにおいて最高計数に対する注射後17分の計数の割合, すなわちcortex retention ratio (CRR) は, 標準型で30%以下, 遅延型で20〜60%, 機能低下型で60〜100%, 閉塞型で100%であり, ERPFとCRRによりパターン間の定量的把握が可能となった. |
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| Practice | 臨床医学：一般 |
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| Keywords | 123I-ortho-iodohippurate, effective renal plasma flow, separate renal function, cortex retention |
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| English |
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| Title | Measurement of Effective Renal Plasma Flow (ERPF) with 123I-Orthoiodohippurate : Comparison between Separate ERPF and Renogram Pattern |
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| Subtitle | Original Articles |
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| Authors | Teruhiko TAKAYAMA*, Akira TADA*, Tamio ABURANO*, Norihisa TONAMI*, Kinichi HISADA*, Masato YAMADA** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, Kanazawa University, **Division of Central Isotope Service, Kanazawa University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 20 |
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| Number | 6 |
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| Page | 841-847 |
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| Year/Month | 1983/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] In order to evaluate separate renal function, effective renal plasma flow (ERPF) was measured with 123I-orthoiodohippurate (OIH) and a scintillation camera interfaced to a computer. Fourty six patients (51 times) were studied following the Tauxe's method with an injection of 500 μCi 123I-OIH. On the posterior view, data were sequentially collected in 1-minute frame for 27 minutes on 64×64 matrix. The blood sample was drawn 44 minutes after injection and was counted using a scintillation counter. In order to calculate separate ERPF, each net renographic curve was integrated for 0-3 minutes after injection. Right and left integrals were expressed as percentage of the total counts. Separate ERPF was obtained by multiplying total ERPF with each resultant fraction. In order to quantify the retention of 123I-OIH in the renal cortex, cortex retention ratio (CRR) was defined from the following formula : CRR=C17/Cmax×100%, where C17 is counts 17 minutes after injection and Cmax is the maximum counts in the cortex renogram. Results of ERPF were evaluated by comparing with each renogram pattern. Results obtained are as follows. 1) ERPF with 123I-OIH was well correlated to that with PAH (paraaminohippurate) : r=0.77 (p<0.01) , y=0.87×+65. 2) Separate ERPF can be validly utilized for the detection of unilateral renal disease. 3) Separate ERPF was more than 100ml/min in the standard pattern and the delayed pattern on the conventional renogram, while less than 100ml/min in the hypofunctional pattern. 4) Cortex retention ratio was less than 30% in the standard pattern, 20 to 60% in the delayed pattern, 60 to 100% in the hypofunctional pattern, and 100% in the obstructive pattern. Therefore, difference of the separate ERPF was recognized among the renogram patterns. |
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| Practice | Clinical medicine |
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| Keywords | 123I-ortho-iodohippurate, effective renal plasma flow, separate renal function, cortex retention |
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