| Japanese |
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| Title | 18FDGポジトロンCT像による局所脳ブドウ糖消費率計測の新しい方法 |
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| Subtitle | 研究速報 |
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| Authors | 遠藤真広*, 宍戸文男**, 福田信男*, 松本徹*, 飯沼武*, 舘野之男*, 山崎統四郎*, 高島常夫***, 田町誓一**** |
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| Authors(kana) | |
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| Organization | *放射線医学総合研究所臨床研究部, **秋田県立脳血管研究センター放射線科, ***千葉県ガンセンター脳神経外科, ****千葉大学医学部脳神経外科 |
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| Journal | 核医学 |
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| Volume | 20 |
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| Number | 5 |
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| Page | 699-702 |
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| Year/Month | 1983/6 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. はじめに」従来, 18F-2-deoxy-2-fluoro-D-glucose (18FDG) の頭部ポジトロンCT像から, 脳局所ブドウ糖消費率 (LCMRGlc) を求めるには, Phelpsらによって始められた平衡状態での18FDGの分布を用いる方法が行われてきた. しかし, この方法には次の2つの欠点がある. すなわち, 1) 投与時から平衡状態に達するまでの間, 動脈血漿中の放射能濃度の時間変化Cp*(t) を詳しく測定する必要がある. 2) 計算に用いる速度定数k1*〜k4*が測定部位の値ではなく正常人の平均値であり, このため梗塞部位など病変部の計算値は実際の値と著しく異なる. われわれはこれらの欠点を克服するため, 18FDG静注後の頭部18FDG像の時間変化から, LCMRGlcおよび速度定数k3*を求める簡便な方法を考案した. この方法では, Cp*(t) の測定は任意の1点のみでよく, また事前に決められた速度定数を用いる必要がない. |
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| Practice | 臨床医学：一般 |
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| Keywords | cerebral glucose metabolism, positron CT, 18FDG |
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| English |
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| Title | A New Method for Analyzing the Local Cerebral Metabolic Rate of Glucose Using an 18FDG Positron CT-image |
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| Authors | Masahiro ENDO*, Fumio SHISHIDO**, Nobuo FUKUDA*, Toru MATSUMOTO*, Takeshi A. IINUMA*, Yukio TATENO*, Toshio YAMASAKI*, Tsuneo TAKASHIMA***, Seiichi TAMACHI**** |
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| Authors(kana) | |
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| Organization | *Division of Clinical Research, National Institute of Radiological Sciences, **Department of Radiology, Research Institute of Brain and Blood Vessels, Akita, ***Department of Neurosurgery, Chiba Cancer Center, ****Department of Neurosurgery, Chiba University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 20 |
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| Number | 5 |
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| Page | 699-702 |
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| Year/Month | 1983/6 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Recently, Phelps et al. have developed a method for analyzing the local cerebral metabolic rate of glucose (LCMRGlc) using an 18FDG positron CT-image. They calculated LCMRGlc from the equilibrium distribution of 18FDG, and their method has become a standard technique. But it has two problems, one of which is the necessity for Cp*(t), that is 18FDG concentration in arterial plasma as a function of time. The other problem is the use of normal values of rate constant k1*〜k4*, which results in significant errors in low metabolic states, such as ischemia. In this report, we proposed a new method by which LCMRGlc is analyzed from time variations of 18FDG distribution after injection. With our method, normal rate constants are not necessary and Cp*(t) is needed at only one point in time. We analyzed some cases with Phelps's method and our method. The results are as follows. 1) There was a good agreement between both LCMRGlc's. 2) In our method, the calculated results were fairly stable against variations of measuring parameters. |
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| Practice | Clinical medicine |
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| Keywords | cerebral glucose metabolism, positron CT, 18FDG |
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