| Japanese |
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| Title | 閉塞性尿路疾患におけるFurosemide負荷利尿99mTc-DTPAレノグラフィ |
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| Subtitle | 原著 |
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| Authors | 油野民雄*, 多田明*, 高山輝彦*, 大口学*, 道岸隆敏*, 利波紀久*, 久田欣一*, 松平正道** |
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| Authors(kana) | |
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| Organization | *金沢大学医学部核医学教室, **附属病院アイソトープ部 |
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| Journal | 核医学 |
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| Volume | 20 |
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| Number | 2 |
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| Page | 205-213 |
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| Year/Month | 1983/3 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTc-DTPA投与15分後に, Furosemide 20 mg (小児 : 0.5mg/kg) 静注の, 利尿剤併用レノグラフィを施行し, その終了後に実施した99mTc-DMSA腎静態シンチグラフィとともに, 閉塞性尿路疾患を評価し, 診断能の向上を試みた. two compartment analysisにより算出したFurosemide利尿による99mTc-DTPAの腎排泄の半減期は, 2.5分以内であり, 閉塞性尿路疾患45例中36例の80%で排泄遅延を呈したが, 非閉塞性疾患でも腎機能障害 (特に高度) で排泄遅延を呈した. したがって, 利尿排泄遅延結果のみでは閉塞性尿路疾患に対する診断的特異性が低かったが, 99mTc-DTPAレノグラフィ上の閉塞型レノグラムパターンおよび腎盂・腎杯の異常像を伴った場合は, sensitivity 71%, specificity 95%, accuracy 85%と著しく診断成績の高い結果が得られた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Obstructive Uropathy, Diuretic Renography, 99mTc-DTPA, Furosemide |
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| English |
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| Title | Furosemide-Assisted Diuretic 99mTc-DTPA Renography in Obstructive Uropathy |
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| Subtitle | Original Articles |
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| Authors | Tamio ABURANO*, Akira TADA*, Teruhiko TAKAYAMA*, Manabu OHGUCHI*, Takatoshi MICHIGISHI*, Norihisa TONAMI*, Kinichi HISADA*, Masamichi MATSUDAIRA** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, School of Medicine, Kanazawa University, **Central Radioisotope Service, Kanazawa University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 20 |
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| Number | 2 |
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| Page | 205-213 |
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| Year/Month | 1983/3 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Diuretic 99mTc-DTPA renography assisted with furosemide was performed in 45 patients with obstructive uropathy and in 93 patients without obstruction, in order to improve the diagnostic efficacy in obstructive uropathy. After hydration of 300 ml of water, 20 mg of furosemide (0.5 mg/kg in children) was injected intravenously 15 min. following 8 mCi of 99mTc-DTPA administration. Serial dynamic images were obtained using scintillation camera every 3 minutes up to 30 min. And data were recorded on to a minicomputer system for 30 min. in 90 frames. To evaluate the effect of furosemide on urinary excretion, the excretion half time (T1/2) was obtained from the faster component on the 99mTc-DTPA excretion curve by two compartment analysis. T1/2 of upper limit was 2.5 min. 80% of patients with obstruction showed a prolonged T1/2. And 57% of patients with non-obstructive renal parenchymal damage also showed a prolonged T1/2. Therefore, it was difficult to separate the patients with obstructive uropathy from the patients with renal parenchymal damage by the results of prolonged T1/2 alone. However, it became quite helpful to separate these two different patients with prolonged T1/2 by evaluating serial dynamic images and renogram. Although frequently seen in patients without obstruction, "so-called" obstructive findings (radionuclide retention in the pelvicalyceal system and obstructive pattern on renogram) were rarely seen in the prolonged T1/2 patients with renal parenchymal damage. With the combined criteria of obstructive findings and prolonged T1/2, 71% of the patients with obstruction were correctly detected, and only 5% of false positives were observed among 93 patients without obstruction. It is suggested that diuretic renography can be useful to differentiate obstructive uropathy from non-obstructive disease in cases of obstructive findings on conventional 99mTc-DTPA renography. |
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| Practice | Clinical medicine |
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| Keywords | Obstructive Uropathy, Diuretic Renography, 99mTc-DTPA, Furosemide |
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