| Japanese |
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| Title | 患者検体測定結果を用いたRIA基準範囲設定の検討 - Hoffmann法の応用 - |
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| Subtitle | 原著 |
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| Authors | 今村恵子*, 佐々木康人**,****, 関田則昭**, 星賢二**, 高橋孝子***, 浅葉文子***, 佐藤あけみ***, 榊徳市***, 染谷一彦***, 藤井正道* |
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| Authors(kana) | |
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| Organization | *聖マリアンナ医科大学放射線医学教室, **第三内科学教室, ***放射線部核医学, ****現東邦大学医学部放射線科 |
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| Journal | 核医学 |
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| Volume | 20 |
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| Number | 1 |
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| Page | 29-35 |
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| Year/Month | 1983/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」実際の患者の年齢構成に見合った正常人検体を集め, 検査室ごとに正常範囲を定めることはなかなか困難である. そこで, 核医学分野への応用が比較的少なかったHoffmann法を用いて, 患者データからRIAの基準範囲を定めることを検討した. Hoffmann法原法ではモード的ガウス分布は確率図から読み取られるが, その際, 偏りが生ずることが明らかとなったので, コンピュータを用いてあてはめを繰返す方法を考案し, T4 (2058件), CEA (760件) について適用した. T4ではモード的ガウス分布は全体の約70%を占め, 患者データ数が800〜900件以上であれば, 得られた基準範囲は互いによく一致した. また, T4, CEAとも得られた基準範囲は従来の正常範囲からみて妥当なものであり, Hoffmann法はRIAにとって有効な方法と考える. 各種RIAの患者データは, コンピュータを用いて自動的な登録を実施している. |
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| Practice | 臨床医学：一般 |
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| Keywords | Radioimmunoassay, Normal range, Hoffmann method, Patient data |
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| English |
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| Title | Assessment of Normal Range in RIA Using Patients' Data - Applications of Hoffmann Method |
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| Subtitle | Original Articles |
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| Authors | Keiko IMAMURA*, Yasuhito SASAKI**, Noriaki SEKITA**, Kenzi HOSHI**, Takako TAKAHASHI***, Humiko ASABA***, Akemi SATO***, Tokuichi SAKAKI***, Kazuhiko SOMEYA***, Masamichi HUZII* |
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| Authors(kana) | |
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| Organization | *Department of Radiology, **Third Division, Department of Internal Medicine, ***Department of Radiology and Nuclear Medicine, St. Marianna University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 20 |
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| Number | 1 |
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| Page | 29-35 |
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| Year/Month | 1983/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] It is not an easy thing to evaluate normal ranges from normal subjects in each laboratory. We applied Hoffmann method to find normal ranges on the basis of patients' data in radioimmunoassays. An improved technique was found to extract model Gaussian distribution through a numerical integration and iterative fitting using a computer. This method is free from a bias which otherwise causes an uncertainty in modal Gaussian distribution. We applied this method to 2058 tests of T4 and 760 tests of CEA. Compared were Hoffmann's normal ranges which were derived from different size of populations, 340 to 2,058 tests of T4. It was confirmed that a population larger than 800 or 900 tests gave a stable and consistent results in case of T4. It could be said in other radioimmunoassays in which the ratio of modal Gaussian distribution is nearly 70% such as T4. Hoffmann's normal range of T4 and CEA were consistent with normal ranges now in use. It could be concluded that Hoffmann method of evaluating a normal range from patients' data is an effective and reliable one in radioimmunoassays also. Patients data are stored automatically in computer disk file in our laboratory. |
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| Practice | Clinical medicine |
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| Keywords | Radioimmunoassay, Normal range, Hoffmann method, Patient data |
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