| Japanese |
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| Title | 201Tl 経直腸投与による門脈循環の非侵襲的診断法 |
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| Subtitle | 原著 |
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| Authors | 利波紀久*, 中嶋憲一*, 久田欣一*, 油野民雄*, 田中延善**, 加登康洋**, 小林健一** |
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| Authors(kana) | |
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| Organization | *金沢大学医学部核医学科, **第一内科 |
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| Journal | 核医学 |
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| Volume | 19 |
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| Number | 10 |
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| Page | 1531-1542 |
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| Year/Month | 1982/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 201Tl-chlorideを経直腸的に投与し, シンチグラフィと解析による新しい門脈大循環の非侵襲的診断法を考案し, 健常13例, 種々の肝疾患65例に試みた. 健常例では 201Tl 直腸内投与後0〜5分像で肝は描出するが, 心, 脾, 肺の集積は非常に乏しかった. これに対し, 門脈大循環短絡を有する肝硬変症と肝細胞障害症例のある症例では肝は明瞭に描画されず, 他臓器特に心の集積が著明となった. 門脈大循環短絡の程度の評価指標として 201Tl 投与20分後の心・肝カウント比を用いたが, 肝硬変では平均値0.92であり, 健常例の0.16, 慢性肝炎の0.25と比べ有意に高値を示した. 肝硬変で食道静脈瘤の存在例は1.06と高値であり, 存在しない例の0.32との間に有意差を認めた. また心・肝比は食道静脈瘤の内視鏡所見分類に基づくStageとの間にも相関が認められた. われわれの結果から本法は非侵襲的に容易に行え, かつ門脈大循環短絡の程度を評価できる非常に優れた診断法となりうると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 201Tl per-rectal administration, Portal systemic circulation, Portal hypertension |
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| English |
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| Title | A New Noninvasive Method for Evaluating Portal Systemic Circulation by Tl-201 Chloride Per-Rectal Administration |
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| Subtitle | Original Articles |
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| Authors | Norihisa TONAMI*, Kenichi NAKAJIMA*, Kinichi HISADA*, Tamio ABURANO*, Nobuyoshi TANAKA**, Yasuhiro KATOH**, Kenichi KOBAYASHI** |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine, **The First Department of Internal Medicine, School of Medicine, Kanazawa University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 19 |
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| Number | 10 |
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| Page | 1531-1542 |
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| Year/Month | 1982/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] A new method for evaluating portal systemic circulation by 201Tl per-rectal administration was developed and performed in 65 patients with various liver diseases and in 13 control subjects. In normal control, the liver was visualized on the 0-5 minutes' image after 201Tl administration, while the heart, spleen and lungs were not clearly visualized even on the 20-25 minutes' image. In patients with portal hypertension, the liver was not clearly visualized, while activities of other organs, especially the heart became great. As the index of estimating the degrees of portal-to-systemic shunt the heart/liver uptake ratio at 20 min. after administration (H/L ratio) was employed. The H/L ratio in liver cirrhosis was significantly higher than those in normal and chronic hepatitis. The patients with esophageal varices showed a significant higher mean H/L ratio compared to that in cirrhotic patients without esophageal varices. There was also a significant difference in H/L ratio between esophageal varices stages. Since there were many other patients with hepatocellular damage who had high H/L ratios similar to those in liver cirrhosis, the effect that hepatocellular damage has on the liver uptake of 201Tl is also considered. Our present data suggest that this noninvasive method seems to be useful to evaluate the degrees of portal-to-systemic shunt. |
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| Practice | Clinical medicine |
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| Keywords | 201Tl per-rectal administration, Portal systemic circulation, Portal hypertension |
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