| Japanese |
|---|
| Title | 末梢循環の研究 - 201Tl による間歇性跛行の定量的評価 - |
|---|
| Subtitle | 原著 |
|---|
| Authors | 浜中大三郎*, 石井靖*, 熊田馨**, 藤田透*, 鳥塚莞爾* |
|---|
| Authors(kana) | |
|---|
| Organization | *京都大学医学部放射線核医学科, **第二外科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 19 |
|---|
| Number | 8 |
|---|
| Page | 1199-1210 |
|---|
| Year/Month | 1982/9 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」 間歇性跛行の程度を定量的評価の対象とするため, 201Tl 静注後の血流分布を安静時および運動負荷時について全身スキャナーにて撮像した. その全身放射能に対する下肢放射能の比を, indicator fractionation principleに従って, 心拍出量に対する局所血流量比 (rBF/CO) として解析した. まず本原理の妥当性を立証するため, 201Tl 静注法における下肢分布と99mTc-MAA動注法におけるそれとを比較した. 両者の相関はr = 0.979ときわめて良好であった. 正常人の片側肢のrBF/COは安静時下肢全体で5.49±0.69%, 大腿部で3.57±0.49%, 下腿部で1.59±0.34%であり, 運動負荷にてそれぞれ19.40±2.04%, 12.26±1.91%, 6.58±0.99%と増加し, その変動率 (ΔrBF/CO) (倍) は, 3.41±0.45, 3.44±0.61, 4.30±1.03であった. 間歇性跛行を主訴とするASO 10例, TAO11例について, その安静時rBF/COに正常との有意差を認めなかったが, ΔrBF/COは前者で1.95±0.40, 後者で1.82±0.47と有意に低下した. 他方イメージ上, 低下欠損部は血管造影所見で予想される部位とよく一致し, そのsensitivity 0.818 specificity 0.916であった. また血管造影で指摘しえない末梢病変のイメージングにも有用と考えられた. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | Quantitative evaluation of intermittent claudication, 201Tl perfusion scintigraphy, Peripheral vascular disease, Exercise loading |
|---|
| English |
|---|
| Title | Quantitative Evaluation of Intermittent Claudication by 201Tl Perfusion Scintigraphy |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Daizaburo HAMANAKA*, Yasushi ISHII*, Kaoru KUMADA**, Toru FUJITA*, Kanji TORIZUKA* |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Radiology and Nuclear Medicine, and **Second Division, Department of Surgery |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 19 |
|---|
| Number | 8 |
|---|
| Page | 1199-1210 |
|---|
| Year/Month | 1982/9 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] Present attempt was to define intermittent claudication objectively by quantitative assessment of 201Tl perfusion scintigraphy of leg both at rest and exercise loading. After intravenous injection of 201Tl with or without exercise loading by treadmil the distribution of this tracer throughout body was obtained using a whole body scanner. According to the indicator fractionation principle, regional blood flow of cardiac output (rBF/co) for each segment of the legs was expressed as a fractional deposited radioactivity (rFU) at these segments of that of whole body. Validity of the principle was confirmed by comparing the depositied activity of 201Tl with that of 99mTc-MMA and a good correlation was found (r = 0.979). rFU in normals was 5.49×0.69% (total leg) 3.57×0.49% (thigh) and 1.59×0.34% (calf) at rest and 19.40×2.04% (total leg) 12.26×1.91% (thigh) and 6.58×0.99% (calf) during exercise. The change ration from the rest to the exercise (ΔrFU) was 3.41×0.45 (total leg) 3.44×0.61 (thigh) and 4.30×1.03 (calf). In patient with known ASO and TAO rFU was within normal range at rest but duing exercise ΔrFU was significantly less than that of normal (1.95×0.40 in the total leg of ASO p < 0.001 ; 1.82×0.47 in the total leg of TAO p < 0.001). A defect or decreased activity on the stress scintigraphy of the legs was wall correlated with the angiographic findings. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | Quantitative evaluation of intermittent claudication, 201Tl perfusion scintigraphy, Peripheral vascular disease, Exercise loading |
|---|