Japanese
Title肺血管外スペースにおける 201Tl 集積の定量的評価
Subtitle原著
Authors藤井忠重*, 平山二郎*, 金井久容*, 半田健次郎*, 草間昌三*, 矢野今朝人**, 滝沢正臣**
Authors(kana)
Organization*信州大学医学部第一内科, **附属病院中央放射線部
Journal核医学
Volume19
Number8
Page1167-1177
Year/Month1982/9
Article原著
Publisher日本核医学会
Abstract「要旨」 201Tl Cl 心筋シンチグラフィーを実施し, 血液中および肺野における放射能量の経時的変化を観察するとともに, 心肺疾患10例で99mTc-アルブミンを併用して血管内および血管外スペースの 201Tl 像を求めた. さらに, 肺血流シンチグラフィーを併用し, 201Tl の肺集積量を投与量に対する百分率 (摂取率) として算出した. 血液中 201Tl 量は急激に減少し, 15分後には1分後の値の5〜15%となり, 肺野の 201Tl 量は約100〜150秒でほぼ一定となるが, 以後も徐々に減少し, 20〜30分後には5分後の値の83.9±10.9%を示した. 種々の肺集積を示す9例において, 肺血管外スペースの 201Tl 像はオリジナルの 201Tl 像に近似し, 前者の肺摂取率は2.8〜15.8%, 平均9.8±5.2%, 後者は3.0〜16.6%, 平均10.1±5.3%となり, 前者は後者の96.8±2.4%を占めた. 201Tl 肺集積は疾患の種類や集積度と無関係に, ほぼ血管外スペースへの集積と考えられる.
Practice臨床医学：一般
KeywordsTl-201, chest scintigraphy, 201Tl-uptake, lung uptake ratio, pulmonary extravascular space
English
TitleThe Quantitative Evaluation of 201Tl-Uptake in the Pulmonary Etravascular Space
SubtitleOriginal Articles
AuthorsTadashige FUJII, Jiro HIRAYAMA, Hisakata KANAI, Kenjiro HANDA, Shozo KUSAMA, Kesato YANO*, Masaomi TAKIZAWA*
Authors(kana)
OrganizationThe First Department of Internal Medicine, Faculty of Medicine, Shinshu University, *Division of Radiology, Shinshu University Hospital
JournalThe Japanese Journal of nuclear medicine
Volume19
Number8
Page1167-1177
Year/Month1982/9
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] 201TlCl chest scintigraphy was performed in 10 patients with various heart and lung diseases, and 201Tl clearances of blood and lung were studied too. Soon after the injection of 201Tl, serial images of the whole chest were recorded in the supine position using a scintillation camera with a small digital computer. Total injected dose (T) was obtained from the maximum radioacivity in the serial images, and that in both lungs (L) was calculated from the anterior image on which the iso-count map of the perfusion lung scintigram was superimposed. Then the lung uptake ratio (%) was calculated by ratio of L/T. Using both scintigrams with 201Tl and 99mTc-human serum albumin, the image of 201Tl in the extravascular space was obtained, and subtracting this image from the original image of 201Tl, the one in the pulmonary extravascular space was obtained. Following results were obtained ; 1) The dissapearance of 201Tl from the blood was rapid, and 15 minutes after the injection only 10-15% of the radioactivity after 1 minute was present. 2) The lung activity of 201Tl on the time activity curve decreased rapidly to reach near plateau within 100-150 seconds after the injection, but slight and gradual decrease of it continued for 30 minutes. 3) The image of 201Tl in the extravascular space was almost the same as the original image of 201Tl as regard to the pattern of 201Tl-distribution. 4) The lung uptake ratio of 201Tl in the pulmonary extravascular space and original image were 9.8+-5.2% and 10.1+-5.3% as mean+-SD, respectively. So the former was 96.8+-2.4% of the latter. 5) The grade of lung uptake of 201Tl was seemed to be a useful index showing the disease process in the pulmonary extravascular space of cardiorespiratory diseases.
PracticeClinical medicine
KeywordsTl-201, chest scintigraphy, 201Tl-uptake, lung uptake ratio, pulmonary extravascular space

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