| Japanese |
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| Title | 心プールイメージングより求めたDiastolic Phase Indexの有用性 - 虚血性心疾患における検討 - |
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| Subtitle | 原著 |
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| Authors | 成田充啓*, 栗原正*, 村野謙一*, 宇佐美暢久*, 本田稔**, 金尾啓右** |
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| Organization | *住友病院内科, **アイソトープ室 |
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| Journal | 核医学 |
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| Volume | 19 |
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| Number | 8 |
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| Page | 1147-1157 |
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| Year/Month | 1982/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 99mTc-multigate心プールイメージングを, 安静時に, 健常14例, 冠動脈疾患 (CAD) 55例で施行, 左室容積曲線より求めたdiastolic phase indexのCADにおける有用性を検討した. Diastolic phase indexとしては, 拡張早期1/3における左室平均充満速度 (1/3FR-mean), 最大充満速度, 充満率の他, 拡張期全体での最大充満速度の4者を求めた. いずれのindexも左室駆出率 (EF) と良好な相関を示し, 再現性も良好であった. CADはEF正常かつ左室壁運動正常のGroup I (26例) と, EFの低下または壁運動異常のあるGroup II (29例) に区分した. いずれのdiastoic diastolic phase indexも健常群, Group I, Group II を区別しえたが, ことに1/3FR-meanでは, 1.70sec-1未満を異常値とみなすことで, CADの91% (Group Iの81%, Group IIの100%) でCADの存在が示唆された. また1/3FR-meanと収縮早期1/3での平均駆出速度との対比を含め, diastolic phase index (ことに1/3FR mean) は, CADの存在を早期より示唆する有用な指標と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | gated blood pool imaging, diastolic phase index, mean first third filling rate, coronary artery disease |
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| English |
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| Title | Usefulness of Diastolic Phase Indexes by Gated Cardiac Blood Pool Imaging in Patients with Coronary Artery Disease |
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| Subtitle | Original Articles |
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| Authors | Michihiro NARITA*, Tadashi KURIHARA*, Kenichi MURANO*, Masahisa USAMI*, Minoru HONDA**, Keisuke KANAO** |
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| Authors(kana) | |
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| Organization | *Department of Internal Medicine, Sumitomo Hospital, **Division of Nuclear Medicine, Sumitomo Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 19 |
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| Number | 8 |
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| Page | 1147-1157 |
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| Year/Month | 1982/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] In patients with coronary artery disease (CAD), various left ventricular diastolic phase indexes were obtained from multi-gated blood pool imaging with 99mTc. As early diastolic phase indexes, during the first third of diastole, filling fraction (1/3FF), mean filling rate (1/3FR-mean) and maximal filling rate (1/3FR-max) were calculated. In addition, maximal filling rate during whole diastole (FR-max) was calculated. These diastolic phase indexes correlated with left ventricular ejection fraction (LVEF) (r >= 0.73, p > 0.001). A good reproducibility was obtained in each of diastolic phase index (r >= 0.96). Subjects were divided into 3 groups : Normal (n = 14), Group I (n = 26) ; CAD with normal LVEF (>=55%) and normal wall motion and Group II (n = 29) ; CAD with reduced LVEF and/or abnormal wall motion. With these diastolic phase indexes, 3 groups could be differentiated (p < 0.001). If we take the mean value minus 2SD of Normal group as the lower limits of normal, diastolic phase indexes were more sensitive to separate CAD from normal subjects (1/3FR-mean > 1/3FF > 1/3FR-max > FR-max in order of sensitivity) than systolic functions such as LVEF, wall motion abnormality and mean first third ejection rate (1/3ER-mean). Abnormality in 1/3FR-mean (<1.70sec-1) was found in 91% of patients with CAD (81% of Group I, 100% of Group II). The comparison of 1/3FR-mean with 1/3ER-mean revealed that early diastolic phase index was sensitive indicator of the left ventricular dysfunction due to myocardial ischemia. |
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| Practice | Clinical medicine |
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| Keywords | gated blood pool imaging, diastolic phase index, mean first third filling rate, coronary artery disease |
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