Japanese
Title心プールイメージングより求めたDiastolic Phase Indexの有用性 - 虚血性心疾患における検討 -
Subtitle原著
Authors成田充啓*, 栗原正*, 村野謙一*, 宇佐美暢久*, 本田稔**, 金尾啓右**
Authors(kana)
Organization*住友病院内科, **アイソトープ室
Journal核医学
Volume19
Number8
Page1147-1157
Year/Month1982/9
Article原著
Publisher日本核医学会
Abstract「要旨」 99mTc-multigate心プールイメージングを, 安静時に, 健常14例, 冠動脈疾患 (CAD) 55例で施行, 左室容積曲線より求めたdiastolic phase indexのCADにおける有用性を検討した. Diastolic phase indexとしては, 拡張早期1/3における左室平均充満速度 (1/3FR-mean), 最大充満速度, 充満率の他, 拡張期全体での最大充満速度の4者を求めた. いずれのindexも左室駆出率 (EF) と良好な相関を示し, 再現性も良好であった. CADはEF正常かつ左室壁運動正常のGroup I (26例) と, EFの低下または壁運動異常のあるGroup II (29例) に区分した. いずれのdiastoic diastolic phase indexも健常群, Group I, Group II を区別しえたが, ことに1/3FR-meanでは, 1.70sec-1未満を異常値とみなすことで, CADの91% (Group Iの81%, Group IIの100%) でCADの存在が示唆された. また1/3FR-meanと収縮早期1/3での平均駆出速度との対比を含め, diastolic phase index (ことに1/3FR mean) は, CADの存在を早期より示唆する有用な指標と考えられた.
Practice臨床医学:一般
Keywordsgated blood pool imaging, diastolic phase index, mean first third filling rate, coronary artery disease
English
TitleUsefulness of Diastolic Phase Indexes by Gated Cardiac Blood Pool Imaging in Patients with Coronary Artery Disease
SubtitleOriginal Articles
AuthorsMichihiro NARITA*, Tadashi KURIHARA*, Kenichi MURANO*, Masahisa USAMI*, Minoru HONDA**, Keisuke KANAO**
Authors(kana)
Organization*Department of Internal Medicine, Sumitomo Hospital, **Division of Nuclear Medicine, Sumitomo Hospital
JournalThe Japanese Journal of nuclear medicine
Volume19
Number8
Page1147-1157
Year/Month1982/9
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] In patients with coronary artery disease (CAD), various left ventricular diastolic phase indexes were obtained from multi-gated blood pool imaging with 99mTc. As early diastolic phase indexes, during the first third of diastole, filling fraction (1/3FF), mean filling rate (1/3FR-mean) and maximal filling rate (1/3FR-max) were calculated. In addition, maximal filling rate during whole diastole (FR-max) was calculated. These diastolic phase indexes correlated with left ventricular ejection fraction (LVEF) (r >= 0.73, p > 0.001). A good reproducibility was obtained in each of diastolic phase index (r >= 0.96). Subjects were divided into 3 groups : Normal (n = 14), Group I (n = 26) ; CAD with normal LVEF (>=55%) and normal wall motion and Group II (n = 29) ; CAD with reduced LVEF and/or abnormal wall motion. With these diastolic phase indexes, 3 groups could be differentiated (p < 0.001). If we take the mean value minus 2SD of Normal group as the lower limits of normal, diastolic phase indexes were more sensitive to separate CAD from normal subjects (1/3FR-mean > 1/3FF > 1/3FR-max > FR-max in order of sensitivity) than systolic functions such as LVEF, wall motion abnormality and mean first third ejection rate (1/3ER-mean). Abnormality in 1/3FR-mean (<1.70sec-1) was found in 91% of patients with CAD (81% of Group I, 100% of Group II). The comparison of 1/3FR-mean with 1/3ER-mean revealed that early diastolic phase index was sensitive indicator of the left ventricular dysfunction due to myocardial ischemia.
PracticeClinical medicine
Keywordsgated blood pool imaging, diastolic phase index, mean first third filling rate, coronary artery disease

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