| Japanese |
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| Title | Tl-201 2回投与法による諸臓器血流分布の評価 - ジピリダモール投与時の影響および虚血性心疾患診断への応用 - |
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| Subtitle | 原著 |
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| Authors | 杉原洋樹*, 足立晴彦*, 鳥居幸雄*, 宮永一*, 西田和夫*, 仁木俊平*, 山田千尋*, 河野義雄*, 古川啓三*, 勝目紘*, 伊地知浜夫*, 宮尾賢爾** |
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| Authors(kana) | |
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| Organization | *京都府立医科大学第二内科, **京都第二赤十字病院内科 |
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| Journal | 核医学 |
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| Volume | 19 |
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| Number | 6 |
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| Page | 903-908 |
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| Year/Month | 1982/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」塩化タリウムを異なる2つの時点で投与し, 第1回投与後に加えられた条件負荷による血流分布率の変化を検出することを目的として本研究を行った. 本法によるジピリダモール0.5mg/kg静注時の諸臓器血流分布の変化率は心筋で38.4%増加し, 肺, 腎, 消化管では減少傾向, 肝は不変であった. 陳旧性心筋梗塞症では心筋の増加率(9.0%)は対照群(67.8%)に比し小さく, また虚血部は正常心筋部よりも小さかった. 本法は種々の条件負荷による血流分布変化を短時間で把握でき, 虚血性心疾患の診断にも応用できるので臨床上有用と考えられる. 「I. はじめに」タリウム201(以下201Tlと略す)心筋シンチグラフィーは非観血的な心筋の血流分布像による虚血性心疾患の診断法として広く用いられている. 201Tlの臓器分布は主に血流分布に依存し, 臓器内摂取後の停留は長いとされ, また物理的半減期は73時間である. |
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| Practice | 臨床医学：一般 |
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| Keywords | Double dose Tl-201 scintigraphy, blood flow distribution, Dipyridamole. |
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| English |
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| Title | Evaluation of Organ Blood Flow Distribution in Man by Consecutive Double Dose Tl-201 Scintigraphy - Effect of Dipyridamole and the Application to Diagnosis of Ischemic Heart Disease - |
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| Subtitle | |
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| Authors | Hiroki SUGIHARA*, Haruhiko ADACHI*, Yukio TORII*, Hajime MIYANAGA*, Kazuo NISHIDA*, Shunpei NIKI*, Chihiro YAMADA*, Yoshio KONO*, Keizo FURUKAWA*, Hiroshi KATSUME*, Hamao IJICHI*, Kenji MIYAO** |
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| Authors(kana) | |
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| Organization | *Second Department of Internal Medicine, Kyoto Prefectural University Medicine, **Department of Medicine, Kyoto Second Red Cross Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 19 |
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| Number | 6 |
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| Page | 903-908 |
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| Year/Month | 1982/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]The initial distribution of Tl-201 in tissue mainly dependent on blood flow. In attempt to evaluate regional blood flow distribution in human organ by Tl-201, we have studied the method to inject two consecutive doses in short interval. Approximate 10 minutes after the first administration of Tl-201, second dose was employed without positional change between a subjective and a camera. Data were acquired 20 frames per 20 minutes, and time activity curves were generated from ROIs on myocardium, lung, liver, kidney, and gastrointestinal organ. Because the activity from the second (C2) is predicted from both that from the first dose (C1) and the dose ratio (R), the difference between predicted activity (C2=R・C1) and measured activity (C2') which was variable according to loading condition means the change in regional blood flow distribution is given as (C2'-C2)/C2. To verify the above rationale, second dose was injected in no loading condition in 10 subjects. The rate of change was -0.95+-5.56% in background subtracted myocardium and converged to near zero in the other organs. The rate of change by Dipyridamole was increased in Myocardium (38.4+-37.6%), decreased in lung, slightly decreased in kidney and gastrointestinal organ and unchanged in liver. In the subjects with focal defects myocardial image due to infarction, the rate of change in whole myocardium was less increased (9.0+-18.8%, p<0.001) than in the controls (67.8+-27.3%). And the rate of change in regional myocardium was increased least in ischemic and less in border than in nonischemic region. Thus this method is useful to evaluate regional blood flow distribution in various organs and even intramyocardium, and then is applicable in pharmacologic or exercise intervention to diagnose myocardial ischemia. |
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| Practice | Clinical medicine |
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| Keywords | Double dose Tl-201 scintigraphy, blood flow distribution, Dipyridamole. |
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