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| Title | Relation of Heparan Sulfate Content and 67Ga Uptake in Various Tissues of Rats |
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| Subtitle | |
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| Authors | Yukie HAMA*, Shuji KOJIMA*, Akiko KUBODERA** |
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| Authors(kana) | |
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| Organization | *Department of Radiopharmacy, School of Pharmaceutical Sciences, Teikyo University, **Department of Radiopharmacy, School of Pharmaceutical Sciences, Science University of Tokyo |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 19 |
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| Number | 6 |
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| Page | 855-861 |
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| Year/Month | 1982/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Abstract]The distribution of 67Ga citrate in various tissues of rats at 24 hrs after i. v. injection was investigated in relation to the heparan sulfate (HS) content of the tissues. The order of 67Ga %dose per g tissue in normal rats was spleen>liver>kidney>stomach>small intestine>heart>lung>muscle>brain. This order is in good accord with that of HS content in these tissues. A comparison of the 67Ga binding affinities with mucopolysaccharides showed that HS has a characteristically high affinity for 67Ga. The binding percent (radioactivity in the precipitate as a percentage of total radioactivity in the incubation mixture) of HS with 67Ga was 95%, but other mucopolysaccharides gave values of about 20% or less. HS appears to play an important role in the mechanism of 67Ga accumulation. |
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| Practice | Clinical medicine |
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| Keywords | Gallium 67, Heparan sulfate, Tissue distribution. |
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| Japanese |
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| Title | ラットの種々の臓器における67Gaの取り込みとHeparan Sulfate量 |
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| Subtitle | 原著 |
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| Authors | 浜幸江*, 小島周二*, 久保寺昭子** |
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| Authors(kana) | |
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| Organization | *帝京大学薬学部放射薬品学教室, **東京理科大学薬学部放射薬品学教室 |
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| Journal | 核医学 |
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| Volume | 19 |
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| Number | 6 |
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| Page | 855-861 |
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| Year/Month | 1982/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | ラットに67Ga citrateを尾静脈内注入して24時間後の種々な臓器における放射活性の分布を臓器のHeparan Sulfate(HS)の量と関連付け検討した. 正常ラットの各種臓器1g当りに取り込まれる67Gaの量は, 脾>肝>腎>胃>小腸>心臓>肺>筋肉>脳の順であった. この順序は, これら臓器のHSの量とよく一致した. また, 種々のムコ多糖類と67Gaの親和性の差を比較すると, HSが67Gaに対して特異的に高い親和性を示した. 以上の結果より, 67Gaの集積機序においてHSは重要な役割を果していることが示唆された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Gallium 67, Heparan sulfate, Tissue distribution. |
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