| Japanese |
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| Title | 癌胎児性抗原CEAのisomeric speciesの分離精製とそのradioimmunoassayの臨床的評価 - 第二編CEAのisomeric speciesのradioimmunoassayによる測定およびその臨床的評価 - |
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| Subtitle | 原著 |
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| Authors | 吉井正雄* |
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| Organization | *京都大学医学部附属病院放射線科 |
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| Journal | 核医学 |
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| Volume | 19 |
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| Number | 3 |
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| Page | 387-397 |
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| Year/Month | 1982/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」著者の精製したCEA-Sと吸収済抗CEA抗血清を用いて二抗体法RIA法を確立し, これにより健常人および各種疾患々者の血清CEA-S値を測定し, 従来のCEA測定法による成績と比較検討した. 健常人の血清CEA-S値はすべて10 ng/ml以下であり, この値を正常上限値とし, これを越える例は陽性とした. 疾患別に陽性率をみると, 非腫瘍性疾患では消化器系疾患で陽性を示す例がみられたが肺結核症ではすべて陰性で, 全体では14.8%の陽性率を示したに過ぎなかった. 悪性腫瘍では消化器系悪性腫瘍で高率に陽性となり, 非消化器系腫瘍では陽性率は著しく低かった. この血清CEA-S値を従来のCEA測定系によるCEA値と比較すると消化器系悪性腫瘍患者以外では, ほとんどがCEA-S値の方が低値を示した. また疾患別の陽性率で比較してみると, 消化器系癌ではほとんど陽性率の差はみられなかったが, 非腫瘍性疾患および非消化器系悪性腫瘍での陽性率はCEA-Sの方が著しく低下した. 以上よりCEA-S測定系は従来のCEA測定系に比べてより消化器特異性, さらには消化器癌特異性が高いと考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | CEA-S, Radioimmunoassay, Tumorrelated antigen, Digestive malignant tumor. |
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| English |
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| Title | II. Clinical Evaluation of Radioimmunoassay of an Isomeric Species of CEA (CEA - S) Using Double Antibody Technique |
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| Subtitle | |
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| Authors | Masao YOSHII |
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| Authors(kana) | |
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| Organization | Department of Radiology and Nuclear Medicine, Kyoto University, School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 19 |
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| Number | 3 |
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| Page | 387-397 |
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| Year/Month | 1982/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Radioimmunoassay using double antibody technique was established for measurement of serum CEA-S values. Serum CEA-S values of 56 normal subjects, 109 patients with non-neoplastic diseases and 220 patients with malignant tumors were measured and the differences of the diagnostic results between the CEA-S assay and conventional CEA assays were compared. All normal subjects showed serum CEA-S values below 10 ng/ml, so 10 ng/ml was determined the value of upper normal limit in the CEA-S assay. In 109 patients with non-neoplastic diseases, some patients with inflammatory digestive and liver diseases showed positive CEA-S values, but only a few patients with non-gastrointestinal diseases showed positive. And in 220 patients with malignant tumors, high positivities of CEA-S values were obtained in patients with malignant digestive and liver tumors, but positivities of CEA-S values were low in patients with non-digestive malignant tumors. When the CEA-S assay and conventional CEA assays were compared, false positive results were lower in the CEA-S assay than in CEA assays, and though positivities in malignant digestive diseases were almost equal in both assays, positivities in non-digestive malignant tumors were lower in the CEA-S assay than CEA assays. Thus the CEA-S assay seemed as sensitive to CEA of digestive origin as CEA assays, but detected only a small subgroups of other organs. CEA-S is considered to be more tumor-specific and more digestive organ specific than conventional CEA. |
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| Practice | Clinical medicine |
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| Keywords | CEA-S, Radioimmunoassay, Tumorrelated antigen, Digestive malignant tumor. |
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