| Japanese |
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| Title | バセドウ病の131I治療例における血清遊離サイロキシン |
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| Subtitle | 短報 |
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| Authors | 斎藤慎太郎*, 桜田俊郎*, 深沢洋*, 吉田克己*, 海瀬信子*, 貴田岡博史*, 山本蒔子*, 海瀬和郎* |
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| Organization | *東北大学医学部第二内科 |
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| Journal | 核医学 |
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| Volume | 18 |
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| Number | 10 |
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| Page | 1421-1424 |
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| Year/Month | 1981/12 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. はじめに」最近, 血中遊離thyroxine(free thyroxine, 以下FT4)がradioimmunoassay(RIA)により測定が可能となって以来, 甲状腺機能に関する新たな知見が見出されてきているが, バセドウ病に対して131I治療(以下131I治療)を行った多数の症例について, FT4を測定した報告はあまり見当らない. このたび著者らは, 前回に次いで, 上記症例に関する長期予後を追跡調査した機会に, それらの例についてFT4を測定した. この調査のうち, 甲状腺機能低下症の発生頻度などに関する臨床成績については他の機会に述べるとして, 本稿においては, FT4と血中T4, triiodothyronine(T3), および甲状腺刺激ホルモン(TSH)などの各値との関係について報告する. 「II. 対象および方法」今回, 131I治療後5〜21年を経た360例について, 血清T4, T3およびTSHを, いずれもRIAによって測定することができたが, これらの中から無作為に286例を選んで, やはりRIAによりFT4をも測定した. |
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| Practice | 臨床医学：一般 |
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| Keywords | Free thyroxine, Graves' disease, 131I Therapy |
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| English |
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| Title | Serum Free Thyroxine after 131I Therapy for Graves' Disease |
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| Subtitle | Short Communication |
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| Authors | Shintaro SAITO, Toshiro SAKURADA, Hiroshi FUKAZAWA, Katsumi YOSHIDA, Nobuko KAISE, Hirofumi KITAOKA, Makiko YAMAMOTO, Kazuo KAISE |
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| Authors(kana) | |
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| Organization | The 2nd Department of Internal Medicine, Tohoku University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 18 |
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| Number | 10 |
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| Page | 1421-1424 |
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| Year/Month | 1981/12 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Serum free T4(FT4)concentrations were measured in 286 patients treated 5-21 years before with 131I for Graves' disease, and these values were compared with serum total T4(T4), total T3(T3)and TSH concentrations. 213 patients(74.4%)had FT4 values within the normal range(0.68-2.00ng/dl), 57(19.9%)had low and 16(5.6%)had high FT4. As a whole, FT4 correlated significantly with T4(p<0.001)and T3(p<0.01). T4 and T3 were in proportion to FT4 in 234 patients (81.8%) and in 227 patients (79.9%), respectively. Furthermore, there existed a definite negative correlation between FT4 and TSH. The TSH was in reverse proportion to FT4 in 223 patients(78%). Out of 103 patients with high TSH(>10μU/ml), 50 patients had low FT4, but 53 had normal FT4. The TSH was significantly higher in the former(low FT4)than in the latter(normal FT4). Moreover, out of 213 patients with normal FT4, 53 patients had high TSH, but 160 had normal TSH. The FT4 in the former(high TSH)was significantly lower than that in the latter(normal TSH). These results indicate that determination of FT4 concentration might be a reliable index of thyroid function after 131I therapy for Graves' disease. |
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| Practice | Clinical medicine |
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| Keywords | Free thyroxine, Graves' disease, 131I Therapy |
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