| Japanese |
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| Title | ジピリダモール負荷201Tl心筋シンチグラフィー - 局所心筋血流予備能の評価 - |
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| Subtitle | 原著 |
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| Authors | 二谷立介*, 瀬戸光*, 柿下正雄*, 亀井哲也*, 寺田康人**, 杉本恒明** |
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| Organization | *富山医科薬科大学医学部放射線医学教室, **第2内科学教室 |
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| Journal | 核医学 |
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| Volume | 18 |
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| Number | 9 |
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| Page | 1287-1294 |
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| Year/Month | 1981/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 局所心筋血流予備能の評価法として, ジピリダモール負荷201Tl心筋シンチグラフィーを施行した. 狭心症を疑った51例で本検査の結果を冠動脈造影所見と比較すると, 75%以上の冠動脈狭窄に対する有病正診率, 無病正診率, 正確度はそれぞれ0.70, 0.89, 0.76と良好だった. さらに冠動脈を3枝に分けて各枝の有意狭窄に対応する区域の201Tl集積低下所見を比較すると無病正診率は0.98と非常に高く, 201Tl集積低下所見は正しく冠動脈病変を表現しているといえる. 一方, 有病正診率は0.48と低かったが, これはガンマカメラの解像力の限界のため左冠動脈末梢部の狭窄の検出率が悪いことによると考えられた. 副作用として冠動脈狭窄患者の36%に前胸部痛が, 57%に心電図上ST-T変化が出現したが, ジピリダモールの拮抗剤のアミノフィリン静注で速やかに消失した. 以上より本検査は局所心筋血流予備能を安全に, 正確に評価出来る方法と言える. |
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| Practice | 臨床医学：一般 |
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| Keywords | Thallim-201, Dipyridamole, Coronary artery disease, Coronary perfusion reserve |
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| English |
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| Title | Thallium-201 Myocardial Scintigraphy on Coronary Vasodilator, Dipyridamole : Assessment of Regional Coronary Perfusion Reserve |
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| Subtitle | Original Articles |
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| Authors | Ryusuke FUTATSUYA*, Hikaru SETO*, Masao KAKISHITA*, Tetsuya KAMEI*, Yasuto TERADA**, Tsuneaki SUGIMOTO** |
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| Authors(kana) | |
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| Organization | *Department of Radiological Sciences and **Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 18 |
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| Number | 9 |
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| Page | 1287-1294 |
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| Year/Month | 1981/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Thallium-201 myocardial scintigraphy on coronary vasodilator, dipyridamole was done to assess their coronary perfusion reserves in 51 patients with suspected angina pectoris. In comparison with coronary arteriography(CAG), sensitivity, specificity and accuracy of this method for 75% coronary stenosis were 0.70, 0.89 and 0.76 respectively. For further analysis, stenotic lesions on CAG were classified into the groups of three coronary vessels and were compared with myocardial scintigrams. Sensitivity was 0.48, however specificity was 0.98, which was very high. From this result, it can be said that a decrease in thallium uptake on scintigram reflects the reduction of regional coronary perfusion reserve accurately. To assess individual stenotic lesion, detectability of the stenoses of left distal coronary artery was low, which could be due to the limitation of spatial resolution ofγ-camera. In 33 patients with 75% coronary stenosis, 36% of them had chest pain and 57% had ST-T change on ECG. These side effects disappeared rapidly with intravenous injection of aminophylline, antagonist of dipyridamole. In conclusion, thallium-201 myocardial scintigraphy on dipyridamole is safe and accurate method to assess regional coronary perfusion reserve. |
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| Practice | Clinical medicine |
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| Keywords | Thallim-201, Dipyridamole, Coronary artery disease, Coronary perfusion reserve |
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