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| Title | Quantitation of Thallium-201 Myocardial Washout by Serial Rest Myocardial Imagin |
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| Subtitle | Original Articles |
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| Authors | Michihiro NARITA*, Tadashi KURIHARA*, Masahisa USAMI*, Minoru HONDA**, Tadashi OGAWA**, Keisuke KANAO** |
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| Organization | *Department of Internal Medicine, Sumitomo Hospital, **Division of Nuclear Medicine, Sumitomo Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 18 |
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| Number | 7 |
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| Page | 899-906 |
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| Year/Month | 1981/8 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Abstract] For quantitative analysis of myocardial thallium-201 clearance, we performed rest serial myocardial imaging in 5 normal volunteers and 20 patients with coronary artery disease. We studied the sequential change of myocardial thallium concentration by using myocardial thallium uptake indices and calculated the half life of the washout of myocardial thallium. Myocardial images obtained in 2 projections were divided into 6 segments and they were classified into 53 normally perfused segments, 41 infarct segments and 26 ischemic segments(defects were observed in 15 of them at the initial myocardial image)on the basis of coronary angiography, radionuclide angiography and ECG findings. Mean halflife of the washout of myocardial thallium in normally perfused myocardium(5.9 +- 1.0 hours in coronary artery disease and 5.6 +- 0.7 hours in normal volunteers)was not different from that of infarcted myocardium(5.7 +- 1.1 hours). On the contrary, the washout rate in ischemic myocardium was very slow and the mean halflife of the washout was 13.1 +- 4.2 hours, and prolonged thallium washout rate was observed in 25 of 26 ischemic segments irrespective of the presence or absence of the defects at the initial myocardial images. In conclusion, the examination of myocardial washout curves can differentiate between 3 different conditions of myocardium and is useful for the detection of ischemic myocardium. |
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| Practice | Clinical medicine |
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| Keywords | Myocardial imaging with thallium, Myocardial washout rate of Tl, Tl-uptake index |
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| Japanese |
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| Title | 安静時経時的タリウム心筋イメージングによるタリウム流出の定量的評価 |
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| Subtitle | 原著 |
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| Authors | 成田充啓*, 栗原正*, 宇佐美暢久*, 本田稔**, 小川正**, 金尾啓右** |
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| Authors(kana) | |
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| Organization | 住友病院 *内科, **アイソトープ室 |
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| Journal | 核医学 |
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| Volume | 18 |
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| Number | 7 |
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| Page | 899-906 |
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| Year/Month | 1981/8 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」 安静時において, 201Tlが心筋内に分布した後の心筋Tlクリアランスを定量的に評価するため, 5例の健常例および20例の冠動脈疾患で, 安静時心筋シンチグラムを, Tl静注5分後から4時間まで経時的に撮影した. 心筋内Tl濃度の変化は, 心筋Tl摂取係数の変化として観察し, これより心筋内Tlの半減期を計測した. 心筋シンチグラムは, 正面, 左前斜位の2方向より, 20分以内に撮影を終了し, 心筋イメージは, 各方向3区域ずつ計6区域に区分した. 冠動脈疾患では, 20例計120の心筋区域を, 冠動脈造影所見, 心電図所見, 99mTcによる心アンギオからえた左室壁運動の性状をもとに, 正常灌流域(53), 梗塞域(41, 全区域でTl注入直後の心筋イメージでdefect存在), 虚血域(26, 内15区域でTl注入直後のイメージでdefect存在)に区分した. 正常灌流城では, 心筋内Tlの半減期は平均5.9 ± 1.0時間(健常例では5.6 ± 0.7時間)で, 梗塞域の5.7 ± 1.1時間の有意差をみなかった. これに反し, 虚血域では, 心筋内Tlのクリアランスは緩徐であり, 半減期は平13.1 ± 4.2時間と有意の延長を示した. また虚血域での心筋内Tlの半減期は, Tl注入直後のイメージでのdefectの存否とは無関係であり, 虚血域26中25で半減期は9時間をこえていた.以上より, 心筋内Tlクリアランスの計測は, 虚血性心疾患において心筋の性状(壊死の有無, 血流状態)の鑑別に有用であり, 殊に, 壊死のない心筋虚血の診断に有用と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Myocardial imaging with thallium, Myocardial washout rate of Tl, Tl-uptake index |
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