| Japanese |
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| Title | ラジオイムノアッセイによるTBG測定の臨床的意義 |
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| Subtitle | 原著 |
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| Authors | 中川毅*, 信田憲行**, 竹田寛*, 平野忠則*, 田口光雄* |
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| Organization | *三重大学医学部放射線医学教室, **三重大学附属病院中央放射線部 |
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| Journal | 核医学 |
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| Volume | 18 |
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| Number | 6 |
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| Page | 809-819 |
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| Year/Month | 1981/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」Radioimmunoassay(RIA-gnost TBG)により血中TBGの測定を行い, その臨床的価値を検討した. 成人の正常値は19.7±1.9μg/ml(mean±SD)に分布した. 甲状腺機能亢進症, 亜急性甲状腺炎, 肝硬変症, sick patientではそれぞれ18.1±3.5, 22.8±4.9, 20.3±7.0, 15.3±3.7μg/mlに分布し, 正常値に比し有意の差を認めず, 甲状腺機能低下症, 妊婦, 胞状奇胎はそれぞれ23.3±2.7(p<0.001), 46.2±6.1(p<0.001), 34.5±6.1μg/ml(p<0.01)に分布し, 有意の高値を示し, TBG減少症は0.4±0.4μg/mlに分布し有意(p<0.001)の低値を示した. 本法によるTBG濃度と電気泳動法によるTBG capacityとの間には良好な相関関係(r=0.967)が認められた. 平衡透析により測定したfree T4とT4/TBG, T4/レゾマットT3, T4/free TBG capacityとの間の相関係数はそれぞれr=0.937, r=0.951, r=0.963であった. TBGの測定は特にTBG減少症, 胞状奇胎の診断, 肝疾患その他sick patientのホルモン結合の判定に有用と思われた. |
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| Practice | 臨床医学：一般 |
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| Keywords | TBG, Radioimmunoassay, Free T4 index |
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| English |
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| Title | Clinical Evaluation of TBG Concentration Measured with Radioimmunoassay Kit |
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| Subtitle | Original Articles |
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| Authors | Tsuyoshi NAKAGAWA*, Noriyuki SHINODA**, Kan TAKEDA*, Tadanori HIRANO*, Mitsuo TAGUCHI* |
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| Organization | *Department of Radiology, Mie University School of Medicine, **Central Clinical Division of Radiology, Mie University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 18 |
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| Number | 6 |
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| Page | 809-819 |
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| Year/Month | 1981/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Serum thyroxine-binding globulin (TBG) was measured with a radioimmunoassay (RIA) Kit (RIA-gnost TBG). The TBG concentration in 19 adult normals was 19.7+-1.9 μg/ml (mean+-SD). The serum TBG levels of 18.1+-3.5 μg/ml in hyperthyroidism, 22.8+-4.9 μg/ml in subacute thyroiditis, 20.3+-7.0 μg/ml in liver cirrhosis and 15.3+-3.7 μg/ml in sick patients were not significantly different from normals. The levels of 23.3+-2.7 μg/ml in hypothyroidism (p<0.01), 46.2+-6.1 μg/ml in pregnancy (p<0.001) and 34.5+-6.1 μg/ml in molar pregnancy (p<0.01) were significantly higher (p<0.01) than that in normals. The levels of 0.4+-0.4 μg/ml in TBG deficiency was significantly lower (p<0.01) than that in normals. The serum TBG level by RIA correlated well with the maximum binding capacity of serum TBG for thyroxine (TBG capacity) (r=0.967). In various cases without thyroid diseases (euthyroid group), the TBG concentration correlated with the value for Res-O-Mat T3 (r=0.948), though there was a curvilinear relationship. This relationship was altered in hyperthyroidism, subacute thyroiditis and molar pregnancy in which sera were overloaded with thyroxine (T4) so that concentrations of unoccupied binding sites on TBG (free TBG concentration) were more decreased than expected from normal TBG concentrations. Hypothyroidism was also separated from the curvilinear relationship in euthyroid group indicating that free TBG concentrations were more increased relative to slightly increased TBG concentrations. Comparisons of various indices for free T4 with the free T4 concentration as measured with equilibrium dialysis revealed that T4/free TBG correlated best with the free T4 concentration (r=0.963) and that T4/Res-O-Mat T3 value (r= 0.951) correlated better than T4/TBG (r=0.937) with the free T4 concentration. Measurement of the TBG concentration was considered useful in the diagnosis of TBG deficiency, in differentiating molar pregnancy from Graves' disease and for correct understanding the hormone-binding in liver diseases and other non-thyroidal illness. |
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| Practice | Clinical medicine |
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| Keywords | TBG, Radioimmunoassay, Free T4 index |
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