| Japanese |
|---|
| Title | 薬剤性肺炎早期検出におけるガリウムシンチグラフィの意義 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 中島秀行*, 沢久*, 高島澄夫*, 小林伸行*, 福田照男*, 越智宏暢*, 小野山靖人*, 栗原直嗣**, 藤本繁夫**, 寺川和彦**, 小林庸次*** |
|---|
| Authors(kana) | |
|---|
| Organization | *大阪市立大学医学部附属病院放射線科教室, **第1内科学教室, **第1病理学教室 |
|---|
| Journal | 核医学 |
|---|
| Volume | 18 |
|---|
| Number | 5 |
|---|
| Page | 583-590 |
|---|
| Year/Month | 1981/6 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」悪性腫瘍患者で化学療法中に, 67Gaシンチグラフィで両側肺野にび漫性のRI異常集積を示した薬剤性肺炎の6症例を経験した. これら6症例の67Ga肺異常集積は胸部X線写真の異常影出現や血液ガスのPO2低下よりも先行して現われた. 症例の原疾患は悪性リンパ腫4例, 子宮癌1例, 急性骨髄性白血病1例で, 悪性リンパ腫症例にはVEM (N) P, 子宮癌例にはbleomycin, 急性骨髄性白血病例にはdaunomycin, cytosine arabinosideを使用しており, これらの薬剤投与期間は13週〜22週で平均15週間であった. 6例中4例は経気管支肺生検で肺胞隔壁の肥厚にリンパ球, 単球, 大食細胞の浸潤があり薬剤性肺炎と診断した. 悪性腫瘍患者で抗癌剤使用中に67Gaシンチで肺野に異常集積像を認めた場合には, 薬剤性肺炎, 悪性腫瘍の肺浸潤, 免疫力低下による肺感染症が考えられ, 鑑別のために肺生検が必要である. このためには肺における異常を早期に検出することが必要で, 薬剤性肺炎の早期検出に67Gaシンチは極めて有用であった. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | 67Ga-scintigraphy, Drug-induced pneumonitis, Chemotherapy, Malignant lymphoma |
|---|
| English |
|---|
| Title | Early Detection of Drug-Induced Pneumonitis by Gallium-67 Lung Scan in Six Patients with Normal Chest Radiographs |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Hideyuki NAKAJIMA*, Hisashi SAWA*, Sumio TAKASHIMA*, Nobuyuki KOBAYASHI*, Teruo FUKUDA*, Hironobu OCHI*, Yasuto ONOYAMA*, Naotsugu KURIHARA**, Sigeo FUJIMOTO**, Kazuhiko TERAKAWA**, Yoji KOBAYADHI*** |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Radiology, Osaka City University, Medical School, **Department of First Medicine, Osaka City University, Medical School, ***Department of First Pathology, Osaka City University, Medical School |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 18 |
|---|
| Number | 5 |
|---|
| Page | 583-590 |
|---|
| Year/Month | 1981/6 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] Increased pulmonary accumulation of Gallium-67-citrate was observed in 6 patients (4 with malignant lymphoma, 1 with uterine cancer and 1 with acute myelocytic leukemia) preceding the appearance of any abnormal findings in both chest X-ray and blood gas data. All of them had received multiple courses of chemotherapy. In these patients, the anticancer drugs were administered for 13 to 22 weeks (mean 15 weeks) . One patient with malignant lymphoma showed abnormal 67Ga lung uptake greater than hepatic activity, 3 patients (malignant lymphoma, 2 and uterine cancer, 1) visualized abnormal 67Ga lung uptake equal to hepatic activity and 2 cases (malignant lymphoma, 1 and acute myelocytic leukemia, 1) demonstrated abnormal accumulation of 67Ga in the lung greater than background activity. In 4 patients (3 with malignant lymphoma and 1 with uterine cancer) out of 6, transbronchial lung biopsy obtained after the 67Ga scans showed nonspecific interstitial pneumonitis with infiltration of lymphocytes and macrophages compatible with drug-induced pneumonitis. In the other 2 patients, cytology and cultures were negative and follow up 67Ga lung scans revealed a reduction in intensity of uptake after treatment with corcicosteroid. Therefore, we considered that the 67Ga lung scan was useful for early detection of drug-induced pneumonitis. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | 67Ga-scintigraphy, Drug-induced pneumonitis, Chemotherapy, Malignant lymphoma |
|---|