Japanese | |
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Title | Iterative deconvolution analysis法によるradionuclide angiocardiographyの解析 - 基礎的検討および臨床への応用 - |

Subtitle | 原著 |

Authors | 前田寿登* |

Authors(kana) | |

Organization | *三重大学医学部附属病院中央放射線部 |

Journal | 核医学 |

Volume | 18 |

Number | 4 |

Page | 473-485 |

Year/Month | 1981/5 |

Article | 原著 |

Publisher | 日本核医学会 |

Abstract | <要旨> Radionuclide(RN)angiocardiographyにおけるRNの注入部位から検査対象臓器までの輸送系の影響を除外するために, iterative deconvolution analysis(IDA)法を用いて解析し, 基礎および臨床応用の両面から検討した. IDAは, 観測および計算出力関数値間に高い相関(R = 0.9994, 10例の平均)を示し, 精度の高いdeconvolution analysis法であることが認められた. IDAをL-to-R shunt疾患におけるQp/Qs比算出に応用し, Oximetry法によるQp/Qs比との比較において, 優れた成績(R = 0.954, N = 22)を得た. IDAにより得られたdeconvoluted curveを用いて動態画像を再構成した. 不適当なRN静注, あるいは心疾患に起因する循環時間の著明な延長などによる不明瞭な左心系イメージにおいても再構成動態画像では, 明瞭な左心系イメージが得られた. 本法の解析操作は比較的簡単で, 短時間で可能であり, 日常診断へ容易に適用でき, RN angiocardiographyの診断精度の向上ができた. |

Practice | 臨床医学：一般 |

Keywords | Deconvolution analysis, Radionuclide angiocardiography, Qp/Qs ratio |

English | |

Title | Deconvolution analysis of circulatory system based on iterative deconvolution method in radionuclide angiocardiography (Fundamental considerations and clinical applications) |

Subtitle | Original Articles |

Authors | Hisato MAEDA |

Authors(kana) | |

Organization | Central Division of Radiology, Mie University Hospital |

Journal | The Japanese Journal of nuclear medicine |

Volume | 18 |

Number | 4 |

Page | 473-485 |

Year/Month | 1981/5 |

Article | Original article |

Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |

Abstract | [Summary] A new method of computing the deconvoluted curve between an observed input and output time-activity curves in radionuclide angiocardiography and its applications to the determination of Qp/Qs ratios in patients with left-to-right shunts and to the dynamic image reconstruction with deconvoluted curves are described here. The method employs an iterative deconvolution analysis. The joint camera-computer system used in these studies consists of the GCA-202 gamma camera and the DAP-5000N computer system. Following intravenous injection of about 10 mCi of 99mTcpertechnetate, 0.2 - 0.6 second frames of data in 64 × 64 matrix form were acquired for a period of 30 seconds utilizing the computer system. The accuracy of the obtained deconvoluted curves was estimated from the values of the correlation coefficient relating the observed output curve and the computed one obtained by convolving the deconvoluted curve with the input curve. In ten cases, the mean value of correlation coefficients was r = 0.9994, being estimated between the main pulmonary artery and the peripheral lung field. It is considered that these excellent results indicate the justice of the iterative deconvolution analysis. In order to determine the Qp/Qs ratios, the deconvoluted curves between the main pulmonary artery and the lung were analized by using the exponential fitting on the first curve and the gamma function fitting on the second one. This method showed a higher correlation (r = 0.954, N = 22)with oximetry than the gamma function method (r = 0.829, N = 22)and several previously reported results. It appears to be superior to the gamma accurate curve fitting, it permits precise quantitation. Sequential dynamic images reconstructed by deconvoluted curves visualized left atrial, left ventricular and aortic configurations with much better quality than originals. |

Practice | Clinical medicine |

Keywords | Deconvolution analysis, Radionuclide angiocardiography, Qp/Qs ratio |