| Japanese |
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| Title | 局所脳循環の連続的測定法の開発 - Kr81m持続動注法を用いて - |
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| Subtitle | 研究速報 |
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| Authors | 小川彰**, 桜井芳明*, 鈴木二郎** |
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| Authors(kana) | |
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| Organization | *国立仙台病院脳卒中センター, **東北大学脳研脳神経外科 |
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| Journal | 核医学 |
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| Volume | 18 |
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| Number | 3 |
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| Page | 329-331 |
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| Year/Month | 1981/4 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. はじめに」臨床的に応用されている脳循環測定法の多くはRI clearance法によるものである. したがって脳血流量の絶対値の測定が可能である反面ごく短時間に反復して測定することは不可能であり, まして脳局所の脳血流量の経時的変化を連続的にしかも臨床の場で測定する方法は現在のところみあたらない. 我々は, Fazioらにより開発された81mKrを用いた脳循環測定法を応用し, 脳の局所でごく短時間にDynamicに変化する脳血流量を連続的に記録する方法を考案した.「II. 方法」81mKrはRb-Kr generator(日本メジフィジックス)に5%glucoseを通過させることにより抽出し, あらかじめ内頸動脈内に留置した21ゲージポリエチレンカテーテルにより持続注入ポンプ(Truth A-II)を用い一定速度(3ml/min)で注入した. Dataの収集は, 頭部側面に設置したγカメラ(TOSHIBA GCA 301)により得られる頭蓋ならびに頸部の側面像のγイメージをData処理装置(TOSHIBA GMS 80A)にon lineに接続して行なった. 1frameのサンプリングタイムは30秒とし60frame 30分間のDataを収集した. |
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| Practice | 臨床医学：一般 |
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| Keywords | regional cerebral blood flow, CO2 response, Krypton-81m |
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| English |
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| Title | Continuous Measurement of Regional Cerebral Blood Flow using Krypton-81m |
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| Subtitle | Rapid Communication |
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| Authors | Akira OGAWA**, Yoshiharu SAKURAI*, Jiro SUZUKI** |
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| Authors(kana) | |
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| Organization | *Stroke Center, Sendai National Hospital, **Division of Neurosurgery, Institute of Brain Diseases, Tohoku University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 18 |
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| Number | 3 |
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| Page | 329-331 |
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| Year/Month | 1981/4 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] In order to obtain the sequential changes of cerebral blood flow using the intracarotid 81mKr infusion method, we devised a new method by using the radioactivity from the cervical internal carotid artery as an indicator of the concentration of radioisotope in the blood perfused to the brain. Under continuous intracarotid injection of 81mKr, the radioactivity obtained from the surface of the skull is proportional to the cerebral blood flow. However, since the method depends upon the infusion of a given volume of radioisotope per unit of time into the internal carotid artery, changes in blood flow through the internal carotid artery result in changes in the concentration of radioisotope perfused to the brain. Under such conditions, the radioactivity obtained from the surface of the skull does not indicate the changes in blood flow. In such a case, the value obtained from the radioactivity (count rate) in the ROI of the brain divided by the concentration of radioisotope in the blood perfused to the brain indicates the changes in cerebral blood flow. Our attention was drawn to the fact that the radioactivity measured from a constant area of the cervical internal carotid artery per unit of time is an indicator of the blood concentration of radioisotope in the internal carotid artery, provided that, there are no changes in the size of the lumen of the internal carotid artery. According to this method devised by us, it has been possible to follow extremely short period changes in cerebral blood flow following CO2 inhalation, change of blood pressure (Autoregulation) and administration of various drugs. |
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| Practice | Clinical medicine |
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| Keywords | regional cerebral blood flow, CO2 response, Krypton-81m |
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