| Japanese |
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| Title | 13C標識トリオクタノインによる脂肪消化吸収試験 - 基礎的問題点 - |
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| Subtitle | 短報 |
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| Authors | 末広牧子*, 山田英夫*, 飯尾正宏*, 中島みゆき**, 森川惇二**, 大沢劉三郎** |
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| Authors(kana) | |
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| Organization | *東京都養育院付属病院核医学放射線部, **栄研I.C.L. 技術 |
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| Journal | 核医学 |
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| Volume | 18 |
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| Number | 2 |
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| Page | 211-214 |
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| Year/Month | 1981/3 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. はじめに」 従来, 脂肪の消化吸収試験に用いられてきた131I-トリオレイン検査法に代わるものとして, Kleinらは, 13C標識脂肪, 脂肪酸による呼気検査を導入した. われわれは, この新しい検査法を試みるにあたり, 基礎的問題点について, 検討を行なったので報告する. 13Cは自然界に約1%存在する安定同位元素で, 放射線を出さないことから, 濃縮13Cを標識した化合物は, 妊婦, 乳幼児にも投与できるということが, この検査の利点である. 「II. 方法」 1) 13C標識脂肪:90%濃縮13Cを標識したトリオクタノイン (Glyceryl-tri[I-13C]-octanoate;Kor社) を用いた. 投与量は, 6.5mg/kg体重とした. 2) 検査法:被験者は, 14〜15時間禁食とし, 31C標識物投与前に, 呼気採取用バッグに呼気を採取された. |
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| Practice | 臨床医学：一般 |
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| Keywords | 13C-trioctanoin, Fat malabsorption |
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| English |
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| Title | 13C-trioctanoin Breath Test for Diagnosis of Fat Malabsorption |
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| Authors | Makiko SUEHIRO*, Hideo YAMADA,*, Masahiro IIO*, Miyuki NAKAJIMA**, Junji MORIKAWA**, Ryuzaburo OHSAWA** |
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| Authors(kana) | |
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| Organization | Department of Nuclear Medicine and Radiological Sciences, Tokyo Metropolitan Geriatric Hospital, **Eiken Immunochemical Laboratory |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 18 |
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| Number | 2 |
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| Page | 211-214 |
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| Year/Month | 1981/3 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Basic studies were performed to evaluate the 13C-trioctanoin breath test for diagnosis of fat malabsorption. 13CO2 coming up into the expired air after oral administration of 13C labeled trioctanoin was analyzed by an isotope ratiometer equipped with a dual collector. 13CO2 increase from the basal 13C abundance was expressed as per mil (‰) . Administration dose was determined by the precision and the detection limit of this analytical method; 2.9 milligrams per kilogram of body weight of 13C-trioctanoin were found to be sufficient to give 100 times higher signal of 13C at the peak time than that of noise level. Fourteen volunteers were chosen for a control study. (Mean: 31.3 y.o.) When they were given 6.5 mg/kg of 13C-trioctanoin, 7 cases showed 71.5+-6.1‰ of peak height at 1.5-2.5 hours after administration and 173+-28‰/5HRS. In another 5 cases, the 13CO2 peak was observed to delay up to 3 hours, and the peak height decreased down to 49.8+-6.3‰. Average 13CO2 redovery in these cases was 126+-25‰HR. In other 2 cases, peak hight and 13CO2 recovery were 33.5+-7.8‰, 77.2+-20.6‰HR, respectively, which suggested the presence of abnormal fat digestion and absorption. |
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| Practice | Clinical medicine |
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| Keywords | 13C-trioctanoin, Fat malabsorption |
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