| Japanese |
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| Title | 急性心筋梗塞におけるミオグロビン遊出量の算定とその臨床的意義 |
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| Subtitle | 《原著》 |
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| Authors | 米倉義晴*, 高坂唯子*, 森田陸司*, 鳥塚莞爾*, 斉藤宗靖**, 平盛勝彦** |
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| Authors(kana) | |
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| Organization | *京都大学医学部放射線核医学科, **国立循環器病センター内科 |
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| Journal | 核医学 |
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| Volume | 17 |
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| Number | 10 |
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| Page | 1201-1209 |
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| Year/Month | 1980/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」急性心筋梗塞について, その発症後, 経時的に血中ミオグロビン(Mb)濃度を測定し, Mb遊出量(ΣMb)を算出した. Mbは発症後9.3±3.9時間でピークに達し, CPK (creatine phosphokinase)の20.1±7.4時間よりも早く, 血中消失率もCPKより大きな値を示した. 梗塞部の大きさを示す指標としてのMbの最大値およびΣMbは, いずれもCPKのそれと有意な正の相関(r=0.86, r=0.84)を示した. Mbの経時的測定は, 急性心筋梗塞の診断および梗塞部の大きさを早期に推定する, 有効な補助診断法となると考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | myoglobin, radioimmunoassay, acute myocardial infarction, infarct size. |
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| English |
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| Title | Quantification of Total Myoglobin Depletion after Acute Myocardial Infarction |
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| Subtitle | - Original Articles - |
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| Authors | Yoshiharu YONEKURA*, Tadako KOSAKA*, Rikushi MORITA*, Kanji TORIZUKA*, Muneyasu SAITO**, Katsuhiko HIRAMORI** |
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| Authors(kana) | |
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| Organization | *Department of Radiology and Nuclear Medicine, Kyoto University, **Department of Medicine, National Cardiovascular Center |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 17 |
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| Number | 10 |
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| Page | 1201-1209 |
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| Year/Month | 1980/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Serum myoglobin (Mb) concentration was measured serially in 23 patients admitted to a coronary care unit because of chest plain. The total amount of myoglobin (ΣMb) released from the myocardium into the circulation was calculated to evaluate the extent of myocardial damage in acute myocardial infarction (AMI), and compared with that of creatine phosphokinase (ΣCPK) which had already been established to estimate the infarct size. Maximum Mb values showed high levels (200 to 5800 ng/ml) in 16 patients with AMI initially examined within 24 hours of the onset of chest pain, whereas didn't in 3 patients with AMI over 48 hours after the onset. Mb showed the maximum value at 9.3 +- 3.9 hours after the onset of AMI, which was significantly (p<0.001) earlier than that of CPK, 20.1 +- 7.4 hours. The disappearance constant (Kd) of Mb in blood was 1.20 +- 0.57 (10-3min-1), greater than that of CPK,0.78 +- 0.24 (10-3min-1). Maximum Mb values and ΣMb correlated well with maximum CPK values (r=0.86) and with ΣCPK (r=0.84), respectively. These results suggest that serial samples for Mb concentration can provide useful diagnostic indices for early assessment of the extent of myocardial damage. |
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| Practice | Clinical medicine |
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| Keywords | myoglobin, radioimmunoassay, acute myocardial infarction, infarct size. |
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