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| Title | Dipyridamole-Loading Myocardial Imaging with Thallium : Basic Investigation of its Usefulness |
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| Authors | Michihiro NARITA*, Tadashi KURIHARA*, Masahisa USAMI*, Minoru HONDA**, Tadashi OGAWA**, Keisuke KANAO**, Shoso NEZUO***, Toshitami SAWAYAMA*** |
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| Authors(kana) | |
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| Organization | *Department of Internal Medicine, Sumitomo Hospital, **Division of Nuclear Medicine, Sumitomo Hospital, ***Department of Cardiology, Kawasaki Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 17 |
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| Number | 8 |
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| Page | 939-942 |
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| Year/Month | 1980/9 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Exercise stress myocardial imaging with thallium-201 (Tl) has been used as a useful noninvasive method for the detection of coronary artery disease (CAD), but its diagnostic accuracy was restricted within the limits of around 75%. Recently, Gould et al reported the validity of dipyridamole-loading myocardial imaging to detect CAD and its possibility to supplement the diagnostic accuracy of the exercise stress myocardial imaging. But little is known about the effect of dipyridamole on myocardial Tl uptake especially in the presence of coronary stenosis. Therefore, we have studied the effect of dipyridamole on myocardial blood flow (MBF) and myocardial Tl concentration by coronary artery occluded dogs to clarify the usefullness of dipyridamole-loading myocardial imaging. We also studied the effect of dipyridamole on Tl concentration in organs adjacent to the heart. [Methods] The 20 adult mongrel dogs (10-16 kg) were anesthetized with sodium pentobarbital (30 mg/kg) and ventilated with a Harvard respirator. After a left thoracotomy, a polyvinyl tube was inserted into the left atrium for the administration of microspheres. In 15 dogs, left anterior descending coronary artery (LAD) was ligated at its middle portion. |
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| Practice | Clinical medicine |
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| Keywords | Thallium-201, Dipyridamole, Myocardial Blood Flow |
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| Japanese |
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| Title | Dipyridamole-Loading Myocardial Imaging with Thallium : Basic Investigation of its Usefulness |
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| Subtitle | 《研究速報》 |
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| Authors | 成田充啓*, 栗原正*, 宇佐美暢久*, 本田稔**, 小川正**, 金尾啓右**, 鼠尾祥三***, 沢山俊民*** |
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| Organization | *住友病院内科, **住友病院アイソトープ室, ***川崎医科大学循環器内科 |
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| Journal | 核医学 |
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| Volume | 17 |
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| Number | 8 |
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| Page | 939-942 |
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| Year/Month | 1980/9 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」Dipyridamole負荷Tl心筋シンチの有効性を検討するため, 冠動脈結紮犬(15頭), 冠動脈狭窄犬(5頭)を用い, dipyridamoleの局所心筋血流量, 心筋内Tl濃度に及ぼす影響を検討した. 冠動脈結紮犬の内対象群では, 局所心筋血流量と心筋内Tl濃度はよく一致した(r=0.927±0.08). Dipyridamole群では, dipyridamoleは, 健常部の心筋血流量を142%増加したが, 心筋内Tl濃度の増加は62%にすぎなかった. しかし健常部と虚血部のTl濃度差はdipyridamoleにより大となった. また冠動脈狭窄犬では, 60%以上の狭窄を有する例で, dipyridamole投与により, 狭窄末梢部で心筋血流量, 心筋内Tl濃度の不均衡を招来した. かつ, 狭窄末梢部での心筋内Tl濃度は健常部の50%以下であった. またこの不均一の度合は, 冠動脈狭窄の程度に平行していた. 以上の結果は, 冠動脈疾患診断におけるdipyiidamole負荷シンチの有用性を示唆した. |
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| Practice | 臨床医学：一般 |
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| Keywords | Thallium-201, Dipyridamole, Myocardial Blood Flow |
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