| Japanese |
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| Title | Dynamic bone scintigraphyによる溶骨性病巣の解析 |
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| Subtitle | 《原著》 |
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| Authors | 熊野町子*, 牛尾啓二**, 末松徹**, 川井和夫***, 水野耕作***, 梶田明義****, 石田修* |
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| Authors(kana) | |
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| Organization | *近畿大学医学部放射線科, **兵庫県立病院がんセンター放射線科, ***神戸大学医学部整形外科, ****大阪府立成人病センター放射線科 |
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| Journal | 核医学 |
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| Volume | 17 |
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| Number | 8 |
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| Page | 911-919 |
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| Year/Month | 1980/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」骨X線写真で溶骨性病巣を示した各種骨疾患26例にdynamic bone scintigraphyを施行し99mTc-MDPあるいは99mTc-EHDPの溶骨性病巣における放射活性を経時的に観察することにより, 骨腫瘍の良性・悪性の鑑別診断の可能性を検討した. dynamic bone scintigraphyを動脈相, 静脈相, 血液プール相(1〜3分), 早期相(5〜20分), static image (3時間後)に分類した. 悪性骨腫瘍20例全例に血液プール相までにRIの高い異常集積がみとめられた. 線維性骨異形成は10分後から異常集積が現われ, static imageでは著明な陽性像として描出された. 骨嚢腫はいずれの相でも欠損像として描画されたが, 骨壊死3例では静脈相からRIの集積が得られ, 疾患による集積性の違が認められた. dynamic bone scintigraphyを応用することにより, 溶骨性病巣の流入血管増生の程度が観察されるなど, 溶骨性病巣の診断に有意義な情報が得られ, 同病巣の良性・悪性の鑑別にもある程度役立つ. 一方, 骨X線像の溶骨性病巣の大きさと, 骨シンチグラム(static image)の所見との関係を検討すると, 2cm以下の溶骨性病巣は13例中11例に陽性像が得られ, 2cmをこえる場合には欠損像(15例中11例)として描出される頻度が増加する. しかし, 線維性骨異形成と悪性巨細胞腫では溶骨性病巣が2cm以上でも陽性像を呈した. 2cm前後の溶骨性病巣で, 周辺に造骨性反応を伴っていない病巣では, 溶骨性病巣が骨X線写真で認められても正常集積像を示した. |
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| Practice | 臨床医学：一般 |
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| Keywords | Dynamic bone scintigraphy, 99mTC-MDP, 99mTc-EHDP, Osteolytic lesion |
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| English |
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| Title | Evaluation of Osteolytic Lesion by Dynamic Bone Scintigraphy |
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| Subtitle | |
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| Authors | Machiko KUMANO*, Keiji USHIO**, Toru SUEMATSU**, Kazuo KAWAI***, Kosaku MIZUNO***, Akiyoshi KAJITA****, Osamu ISHIDA* |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Kinki University School of Medicine, **Department of Radiology, Hyogo Cancer Hospital, ***Department of Orthopedics, Kobe University School of Medicine, ****Department of Radiology, The Center for Adult Disease |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 17 |
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| Number | 8 |
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| Page | 911-919 |
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| Year/Month | 1980/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] In 26 patients with osteolytic lesions detected by X-ray examination, dynamic scintigraphy with Tc-99m MDP was performed to evaluate skeletal abnormalities, particularly in osteolytic lesions. Sequential scintigraphy was performed all through the arterial, venous, capillary and early phases. Static images also were taken 3 hours after then. Local short-term deposition of the tracer in malignant bone lesions was observed in the capillary phase (less than 2 min. after the injection). However, in benign bone lesions it was not observed until the early phase (more than 10 min.). "Hot" lesions were demonstrated even in small osteolytic changes of less than 2 cm in diameter, The findings suggest that there is a correlation between tracer uptake and increased metabolic activity. "Cold" lesions in bone due to reduced uptake of Tc-99m MDP were found in extensive osteolytic lesions, particularly in those lesions with osteolytic changes of greater than 2 cm in diameter. Scintigraphic differentiation of the benign bone tumor from the malignant bone tumor was facilitated by adding a dynamic scan with the early phase study immediately after the injection of the tracer. |
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| Practice | Clinical medicine |
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| Keywords | Dynamic bone scintigraphy, 99mTC-MDP, 99mTc-EHDP, Osteolytic lesion |
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