Japanese
Title虚血性心疾患におけるthallium-201心筋シンチグラフィー - 体表計測によるthallium-201の経時的変化ならびに心筋血流量測定に関する検討 -
Subtitle《原著》
Authors大和田憲司*, 束原康文*, 阿部裕光*, 小野和男*, 蛯谷勧*, 室井秀一*, 松田信*, 池田精宏*, 待井一男*, 内田立身*, 木田利之**, 刈米重夫*
Authors(kana)
Organization*福岡県立医科大学第1内科, **福島県立医科大学放射線科
Journal核医学
Volume17
Number8
Page891-899
Year/Month1980/9
Article原著
Publisher日本核医学会
Abstract「要旨」陳旧性心筋梗塞34例, 狭心症13例にタリウム201心筋シンチグラフィーを行ない, 心筋血流量MBF/CO(%)とMBF (ml/min/m2)を算出し, 検討した. 6例については, 各臓器での放射能集積の変化を観察した. 1)タリウム-201の体表計測では, 5分から50分後まで, 心, 肺, 肝, 腎において, ほぼ一定の放射能集積を示したが, 心不全例では, 血液中の放能能クリアランスが遅延し, 肺での放射能が多かった. 2) MBF/CO(%)は, 対照群で3.49±0.45%, 心筋梗塞群で2.84±0.47%, 狭心症群で3.00±0.37%で, 後者の2群で有意に低値を示した. 3) MBF (ml/min/m2)は対照群では100.4±12.7 ml/min/m2, 心筋梗塞群では80.5±21.1, 狭心症群では77.3±15.4と, 後者の2群で低値を示し, CPK高値の心筋梗塞例ではMBFが有意に減少した. 以上より, MBFは心筋梗塞や狭心症例において, 心筋血流の減少度合を反映すると結論した.
Practice臨床医学：一般
Keywordsmyocardial blood flow, thallium-201 scintigraphy, ischemic heart disease, body surface radioactivity
English
TitleClinical Studies on the Thallium-201 Myocardial Scintiphotography in the patients with Ischemic Heart Diseases : Studies in Organ Distribution of Thallium-201 and in the Measurement of Myocardial Blood Flow
Subtitle
AuthorsKenji OWADA, Yasunori TSUKAHARA, Hiromitsu ABE, Kazuo ONO, Susumu EBITANI, Shuichii MUROI, Shin MATSUDA, Kiyohiro IKEDA, Kazuo MACHII, Tatsumi UCHIDA, Toshiyuki KIDA*, Shigeo KARIYONE
Authors(kana)
OrganizationFirst Department of Internal Medicine, and *Department of Radiology, Fukushima Medical College
JournalThe Japanese Journal of nuclear medicine
Volume17
Number8
Page891-899
Year/Month1980/9
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] Thallium-201 (201Tl) myocardial scintiphotography was performed in 34 patients with myocardial infarction and 13 with angina pectoris. Changing pattern of 201Tl activity in various organs observed. Myocardial blood flow was calculated from the relation of these activities. The body surface radioactivity of 201Tl decreased rapidly in initial phase, it gradually slowed down then reached to plateau on the heart and the lungs, while it increased gradually on the liver and kidneys. In patients with congestive heart failure, blood clearance of 201Tl was delayed and radioactivity on the lung area was increased compared with normal case. MBF/CO (%) ratio was calculated by the following way. Soon after the injection of 201Tl, serial images including whole chest were taken one frame in each one second during 30 seconds. Total injected dose was calculated from the maximum radioactivity in the frame. Myocardial uptake was calculated by the anterior view subtracting the mediastinal activity as the background at 5 minutes after the injection. MBF/CO (%) ratio was calculated as the myocardial uptake divided by the activity of total injected dose. Its mean value were 3.49 +- 0.45% in normals, 2.84 +- 0.47% in myocardial infarction and 3.00 +- 0.37% in angina pectoris, respectively, which showed significant low values in the latter two groups. The cardiac output was measured by dye dilution method, then myocardial blood flow (MBF) was calculated by the following fomula; MBF (ml/min/m2)=MBF/CO (%)×Cardiac index (CI). The mean value of MBF was 100.4 +- 12.7 ml/min/m2 in normals, 80.5 +- 21.1 in myocardial infarction and 77.3 +- 15.4 in angina pectoris, respectively, showing also significant low values in the latter two groups. Especially, MBF was most significant low in the groups of myocardial infarction with high serum CPK values. It is concluded that MBF (ml/min/m2) value is more useful than MBF/CO (%) ratio for the expression of coronary blood flow.
PracticeClinical medicine
Keywordsmyocardial blood flow, thallium-201 scintigraphy, ischemic heart disease, body surface radioactivity

【全文PDF】