| Japanese |
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| Title | アロキサン処理ラットにおけるラジオレスピロメトリックパターンの解析 |
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| Subtitle | 《原著》 |
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| Authors | 小島周二*, 浜幸江*, 広川幸雄**, 醍醐公彦**, 志気保子**, 久保寺昭子** |
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| Authors(kana) | |
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| Organization | *帝京大学薬学部放射薬品学教室, **東京理科大学薬学部放射薬品学教室 |
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| Journal | 核医学 |
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| Volume | 17 |
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| Number | 7 |
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| Page | 775-780 |
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| Year/Month | 1980/8 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」アロキサン処理したラットの[U-14C] glucoseを基質としたラジオレスピロメトリックパターンを肝糖代謝酵素活性変化と関連付け検討し, 以下の結果を得た. 1)初期高血糖期におけるラジオレスピロメトリックパラメーターの変化は, 肝解糖系酵素活性変化と良い相関が認められた. peak time (PT)は, アロキサン投与後10〜20分では早まる傾向にあるが, その後24時間まではやや遅れた. peak height (PH), yield value (YV)は共に投与後30〜40分でコントロール値の1/2に低下するが, 24時間後には回復した. 一方肝解糖系酵素, 特にhexokinase (HK)は30〜40分後にコントロール値の約50%まで抑制された. 2)初期高血糖期における血糖値の上昇は, 肝HKの不活性化によることが示唆された. 3)ラジオレスピロメトリーが, 傷害肝における糖代謝を検索する有益な手段となり得ることがより明らかとなった. |
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| Practice | 臨床医学：一般 |
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| Keywords | Radiorespirometry, Alloxan, Hexokinase |
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| English |
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| Title | Analysis of Radiorespirometric Pattern in the Rat Treated with Alloxan |
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| Subtitle | - Original Articles - |
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| Authors | Shuji KOJIMA*, Yukie HAMA*, Yukio HIROKAWA**, Kimihiko DAIGO**, Yasuko SHIKI**, Akiko KUBODERA** |
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| Authors(kana) | |
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| Organization | *Faculty of Pharmaceutical Sciences, Teikyo University, **Faculty of Pharmaceutical Sciences, Science University of Tokyo |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 17 |
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| Number | 7 |
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| Page | 775-780 |
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| Year/Month | 1980/8 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Radiorespirometric pattern using [U-14C] glucose as a substrate was analyzed in the rat treated with alloxan in connection with the liver glycolytic enzyme activities. The results were as follows: (1) The radiorespirometric parameters at an early stage of hyperglycemia altered in connection with those of the liver enzyme activities, Peak time (PT) tended to hasten at 10-20 minutes after the treatment of alloxan, but thereafter delayed up to 24 hours. Both peak height (PH) and yield value (YV) decreased immediately after the treatment to half as much as those of control at 30-40 minutes. At 24 hours after, they recovered to the control levels. On the other hand, the liver glycolytic enzyme, hexokinase (HK) activity in particular was inhibited to about 50% of the control at 30-40 minutes. (2) The increase of blood sugar level at an early stage was probably due to the inactivation of liver HK by alloxan itself. (3) The method of radiorespirometry is a useful technique for study of glucose metabolism in liver injury. |
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| Practice | Clinical medicine |
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| Keywords | Radiorespirometry, Alloxan, Hexokinase |
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