| Japanese |
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| Title | 冠動脈の結紮時ならびに再灌流時の心筋シンチグラフィー - 特に99mTc-PYPによるimagingの特性に関しての実験的研究 - |
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| Subtitle | 原著 |
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| Authors | 永井義一*, 野原義次*,** |
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| Authors(kana) | |
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| Organization | *東京医科大学内科第2講座, **指導 |
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| Journal | 核医学 |
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| Volume | 17 |
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| Number | 6 |
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| Page | 675-690 |
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| Year/Month | 1980/7 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」犬心の左冠動脈前下行枝を結紮し, 実験的に心筋梗塞を作成した. そして99mTc-PYPの虚血部における動態を観察し, また, 結紮冠動脈を再灌流した際の変動をもあわせて検討し, 以下の成績をえた. (1) 99mTc-PYPとFluorescein Na螢光法による虚血範囲は前者の方が大であった. (2) 虚血部位への99mTc-PYPの取り込みは結紮7日後までは鮮明に描記しえたが, それ以後しだいにその取り込みは低下し, 11日後には虚血部位の識別は不可能となった. (3) 再灌流群では40分以上結紮し再灌流した際に虚血部への99mTc-PYPの取り込みが出現した. また, 結紮冠動脈と再灌流群とを比較すると, 99mTc-PYPによる虚血部位の識別できる期間は後者の方が延長していた. (4) 病理組織学的に急性像を呈している間は99mTc-PYPの虚血部への取り込みが多く, その虚血心筋の線維化の程度と範囲が増すにつれて, 虚血部位と健常部位の境界がしだいに不鮮明となっていった. |
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| Practice | 臨床医学：一般 |
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| Keywords | Technetium-99m pyrophosphate, Coronary occlusion, Coronary reperfusion, Fluorescein Na method, Histopathology |
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| English |
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| Title | Experimental Studies on Myocardial Scintigraphy, Especially, Characteristic Imagings of 99mTc-Pyrophosphate after Coronary Artery Ligation and Reperfusion |
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| Subtitle | Original Articles |
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| Authors | Yoshikazu NAGAI*, Yoshitsugu NOHARA*,** |
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| Authors(kana) | |
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| Organization | *The Second Department of Internal Medicine, Tokyo Medical College, **Director Professor |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 17 |
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| Number | 6 |
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| Page | 675-690 |
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| Year/Month | 1980/7 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] By ligating the descending branch of the left coronary artery, myocardial infarction in dogs was induced for experimental purposes. The findings as shown by 99mTc-PYP in the ischemic myocardium were observed at different periods of time after ligation, as well as after reperfusion of the ligated coronary artery. 1) Measurements of the ischemic area were taken using both the 99mTc-PYP and Fluorescein Na methods. The measurements using the former method were found to be larger than those using the latter. 2) For a period of up to 7 days after ligation, image produced by 99mTc-PYP in the ischemic myocardium could be clearly observed, but after that the images in the ischemic myocardium began to decrease. Thus, 7 days after ligation it became increasingly harder to distinguish the ischemic area from the healthy area until, after 11 days, the two areas were indistinguishable. 3) In reperfusion groups, uptake of 99mTc-PYP in the ischemic area began to appear in reperfusion after 40 min's ligation. Comparing coronary ligation and reperfusion, the period during which the ischemic area could be distinguished by 99mTc-PYP was observed to be longer in the latter. 4) Histologically, in periods within 7 days after ligation, the influx of 99mTc-PYP was observable because early degeneration of the ischemic myocardium had occurred. About 7 days after ligation, the degree and extent of fibrosis had spread and it became harder to distinguish between the images provided by 99mTc-PYP in the ischemic area and the healthy area. |
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| Practice | Clinical medicine |
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| Keywords | Technetium-99m pyrophosphate, Coronary occlusion, Coronary reperfusion, Fluorescein Na method, Histopathology |
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