| Japanese |
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| Title | 99mTc-Antimony Sulfide Colloid (ASC) の網内系集積性 - 99mTc-硫黄コロイドとの比較 - |
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| Subtitle | 短報 |
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| Authors | 長井一枝*, 伊藤安彦*, 大塚信昭*, 村中明*, 加地辰美*, 寺島秀彰*, 柳元真一* |
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| Authors(kana) | |
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| Organization | *川崎医科大学核医学教室 |
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| Journal | 核医学 |
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| Volume | 17 |
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| Number | 5 |
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| Page | 583-587 |
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| Year/Month | 1980/6 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「はじめに」 放射性コロイド貪食に基づく骨髄スキャニングは, 各種血液疾患および癌の骨髄内転移の有用な検査手段であり, 198Auコロイド (以下Au-コ と略記) , 99mTc-硫黄コロイドを始めとし各種99mTc-標識コロイドが使用されている. しかし, Itoらの成績では, ほとんどすべてのコロイドにおいて投与量の70〜90%が肝に摂取され, 骨髄集積はきわめて少ない. また, コロイドの種類によっては尿中へ排泄され膀胱が描画される場合があり, コロイドの性状から考えるといずれも優れた骨髄スキャニング剤とは言えないものが多い. 99mTc-アンチモンコロイドは1965年にGarzonらによって発表され, 近年, Egeらの報告をはじめ, リンパ節スキャニング剤としてその有用性が報告されている. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-ASC, Bone marrow scintigraphy, Lymph node scintigraphy |
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| English |
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| Title | Experimental Studies on Accretion of 99mTc-Antimony Sulfide Colloid in RES : A Comparison with 99mTc-Sulfur Colloid |
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| Subtitle | Short Communication |
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| Authors | Kazue NAGAI, Yasuhiko ITO, Nobuaki OTSUKA, Akira MURANAKA, Tatsumi KAJI, Hideaki TERASHIMA, Shin-ichi YANAGIMOTO |
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| Authors(kana) | |
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| Organization | Division of Nuclear Medicine, Kawasaki Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 17 |
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| Number | 5 |
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| Page | 583-587 |
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| Year/Month | 1980/6 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] 99mTc-Antimony Sulfide Colloid (ASC) was originally prepared for a purpose of making particle size smaller. With this property, usefulness of ASC for bone marrow and lymph node scintigraphies including basic studies was evaluated. First, ASC was subjected to thin layer chromatography and electron microscopy. Second, blood clearance, tissue distribution study and scintigraphy were carried out on rabbits, being compared with 99mTc-sulfur colloid (TCK-1) . Particles were spherical and uniform. The diameter ranged mostly from 4.5 to 16.5 nm, The labeling yield was more than 95% even 24 hrs after preparation. Blood clearance, T1/2 was 2 min. Residual activity in blood was about 9% 30 min after injection. Liver uptake was 52.8% and marrow uptake was 20.6%. Urinary excretion was 0.9% in 30 min. Because of high uptake by marrow, excellent imaging was obtained, compared with TCK-1. As for lymphoscintigraphy, accretion in lymph node with ASC was much greater than with TCK-1. ASC is considered to be superior to TCK-1 and would be of value in marrow scintigraphy and lymphoscintigraphy as well. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-ASC, Bone marrow scintigraphy, Lymph node scintigraphy |
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