| Japanese |
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| Title | 悪性腫瘍診断における血清フェリチン値および血清鉄値測定の有用性について |
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| Subtitle | 原著 |
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| Authors | 吉井正雄*, 高坂唯子*, 中島言子*, 森田陸司*, 鳥塚莞爾** |
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| Authors(kana) | |
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| Organization | *京都大学医学部附属病院放射線部, **京都大学医学部附属病院放射線核医学科 |
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| Journal | 核医学 |
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| Volume | 17 |
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| Number | 3 |
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| Page | 317-323 |
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| Year/Month | 1980/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」各種疾患患者の血中ferritin値と血清鉄値を同時に測定し, その比をみることによって悪性腫瘍診断における有用性について検討した. 健常人では比は1.0近傍に分布し, 鉄欠乏性貧血では1.0以下を示した. 再生不良性貧血, ヘモクロマトーシスおよび慢性腎不全では高値を示すものが多かったが, 非腫瘍性疾患では比はほとんどが10以下であり, 20を越えるものはなかった. 悪性腫瘍患者では全般に高値を示すものが多く, 104例中54例 (51.9%) が10以上を示し, 24例 (23.1%) が20以上を示した. 従って, 血清ferritin値と血清鉄値の比が20を越える症例はまず悪性腫瘍と診断でき, 10以上を示すものは悪性腫瘍が強く疑われ, 「比が10以上」が悪性腫瘍診断の一つの指標になり得ると考えられた. また, この比は原発性肝癌と慢性肝炎および肝硬変症の鑑別にも有用であった. |
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| Practice | 臨床医学：一般 |
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| Keywords | Ferrtin, Ferritin-Iron Ratio, Malignant Tumors, AFP, Hepatoma |
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| English |
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| Title | Clinical Evaluation of Serum Ferritin-Iron Ratio in the Diagnosis of Malignant Diseases |
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| Subtitle | Original Articles |
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| Authors | Masao YOSHII, Tadako KOHSAKA, Kotoko NAKAJIMA, Rikushi MORITA, Kanji TORIZUKA |
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| Organization | Central Clinical Radiology and Radioisotope Division, and Department of Radiology and Nuclear Medicine, Kyoto University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 17 |
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| Number | 3 |
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| Page | 317-323 |
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| Year/Month | 1980/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Serum ferritin and iron levels were measured in 35 normal subjects and 248 cases with various diseases. In normals, the serum ferritin levels ranged from 30 to 180 ng/ml. Elevated serum ferritin was observed in patients with aplastic anemia, hemochromatosis, chronic renal failure and acute hepatitis. In malignancy, the levels distributed markedly high in the majority of cases with acute leukemia, malignant lymphoma, hepatoma and pancreatic cancer. High ferritin levels were also seen in other malignant diseases. However, the range overlapped widely with that of non-malignant diseases. The serum ferritin significantly correlated with serum iron in normals and iron deficiency anemia (r=0.89, n=95) . In most non-malignant cases, the serum ferritin and iron levels distributed on a regression line obtained from the normals and iron deficiency anemia. On the contrally, in the majority of patients with malignant diseases the serum ferrtin distributed significantly higher than expected for the serum iron levels observed. Then the ratio of serum ferritin to serum iron levels was calculated in each cases. The ratio ranged from 0.5 to 1.7 for normals with a mean of 1.04. Though relatively high values of the ratio were observed in the patients with non-malignant diseases, the ratio exceeded 10 in only 12 cases of 144 nonmalignant diseases, but exceeded 20 in none of them. The values ranged widely from low to high in malignant diseases, the majority of them showed high ferritin-iron ratio. The ratio exceeded 10 in 54 cases of 104 malignant diseases (51.9%) and did 20 in 24 cases (23.1%) . Thus it was considered that a case with the ratio over 10 was suspicious of malignancy. Furthermore the ratio was useful in differentiating hepatoma from chronic hepatitis and liver cirrhosis. |
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| Practice | Clinical medicine |
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| Keywords | Ferrtin, Ferritin-Iron Ratio, Malignant Tumors, AFP, Hepatoma |
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