| Japanese |
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| Title | 99mTc-E-HIDAによる肝胆道シンチグラフィーおよび機能診断に関する実験的, 臨床的研究 |
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| Subtitle | 原著 |
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| Authors | 楢林勇*, 大塚信昭*, 寺島秀彰*, 横林常夫*, 加地辰美*, 伊藤安彦* |
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| Organization | *川崎医科大学放射線科核医学教室 |
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| Journal | 核医学 |
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| Volume | 17 |
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| Number | 2 |
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| Page | 167-175 |
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| Year/Month | 1980/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」動物実験にて99mTc-E-HIDAの体内分布を99mTc-p-butyl-IDA, 123I-RBなどの動態と比較検討し, また, 臨床例では, 閉塞性黄疽および肝障害を含む20例を対象として肝胆道系放射性薬剤としての有用性を検討した. 99mTc-E-HIDA静注1時間後の家兎の組織内分布は胆嚢, 腸管内に投与量の約62%が分布し, 肝に約2%, 腎尿路系への排泄は約9%であった. また, 99mTc-E-HIDAの標識率の検討のため, 薄層クロマトグラフィーを行ない, フリーの99mTcO4-はほとんど存在しないことを確認した. 臨床例において, 99mTc-E-HIDAによる経時的肝胆道シンチグラフィーは肝, 胆管, 胆嚢, 腸管を鮮明に描出し, 肝摂取のある限り腎への排泄は少なかった. 99mTc-E-HIDAの血中停滞率, 血中クリアランスがある程度病態を反映しており, hepatogram上の肝排泄率が肝胆道機能をよく現わし得た. |
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| Practice | 臨床医学：一般 |
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| Keywords | 99mTc-E-HIDA, Hepatobiliary scintigraphy, Hepatobiliary function test |
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| English |
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| Title | Experimental and Clinical Studies on Hepatobiliary Scintigraphy and Function Test with 99mTc-E-HIDA |
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| Subtitle | Original Articles |
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| Authors | Isamu NARABAYASHI, Nobuaki OTSUKA, Hideaki TERASHIMA, Tsuneo YOKOBAYASHI, Tatsumi KAJI, Yasuhiko ITO |
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| Authors(kana) | |
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| Organization | Division of Nuclear Medicine, Kawasaki Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 17 |
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| Number | 2 |
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| Page | 167-175 |
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| Year/Month | 1980/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] : In experimental and clinical studies, the usefulness of 99mTc-E-HIDA has been evaluated for dynamic imaging and function test. Biological distribution of 99mTc-E-HIDA in rabbits at 1 hour after the intravenous administration indicated that activity was 62% of the injected dose in the gallbladder and intestine, 2% in the liver, and 9% in the kidneys and urine. Hepatic uptake and excretion of 99mTc-E-HIDA were discussed in comparison with those of 99mTc-p-butyl-IDA, 99mTc-HIDA, 99mTc-PI and 123I-RB. Radiochemical purity was ascertained by thin layer chromatography in saline. Labelling was nearly 100%, namely no unreacted pertechnetate was detected. In clinical study, the imaging of liver, bile ducts, gallbladder and intestine was satisfactory with 99mTc-E-HIDA. There was no or faint renal visualization in cases with hepatic uptake on the hepatogram. Quantitative analysis of blood retention, blood clearance and hepatogram with 99mTc-E-HIDA reflected excretory liver function in various hepatobiliary disorders. We concluded that 99mTc-E-HIDA has a lower urinary excretion and seems more effective than the other 99mTc-labels, such as 99mTc-HIDA and 99mTc-PI, at higher bilirubin levels. However, when the level of the bilirubin in blood rises above 7.4 mg/dl, no hepatic uptake of 99mTc-E-HIDA was obtained with greater renal excretion. |
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| Practice | Clinical medicine |
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| Keywords | 99mTc-E-HIDA, Hepatobiliary scintigraphy, Hepatobiliary function test |
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